Your search returned 117 studies. (Get alerts for new studies):
- Comparison of Pixantrone + Rituximab With Gemcitabine + Rituximab in Patients With Aggressive B-cell Non-Hodgkin Lymphoma or Follicular Grade 3 Lympho
Conditions: Diffuse Large B-cell Lymphoma - de Novo DLBCL - DLBCL Transformed From Indolent Lymphoma - Follicular Grade 3 Lymphoma Location: Danville, Illinois
- Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
Conditions: Colorectal Cancer Location: Lafayette, Indiana
- Tamoxifen or Letrozole With or Without Bevacizumab in Treating Women With Stage III or Stage IV Breast Cancer
Conditions: Breast Cancer Location: Lafayette, Indiana
- Melphalan, Prednisone, and Thalidomide or Lenalidomide in Treating Patients With Newly Diagnosed Multiple Myeloma
Conditions: Multiple Myeloma and Plasma Cell Neoplasm Location: Lafayette, Indiana
- Laparoscopic-Assisted Resection or Open Resection in Treating Patients With Stage IIA, Stage IIIA, or Stage IIIB Rectal Cancer
Conditions: Colorectal Cancer Location: Mooresville, Indiana
- Uniglide™ Mobile Bearing Unicondylar Knee System vs the Uniglide™ Fixed Bearing Unicondylar Knee System
Conditions: Osteoarthritis Location: Indianapolis, Indiana
- Biorepository: Indiana Health Study
Conditions: Coronary Artery Disease - Heart Disease - Healthy Location: Indianapolis, Indiana
- Docetaxel, Carboplatin, and Trastuzumab and/or Lapatinib in Treating Women With Stage I, Stage II, or Stage III Breast Cancer That Can Be Removed by S
Conditions: Breast Cancer Location: Haute Terre, Indiana
- Lenalidomide With or Without Epoetin Alfa in Treating Patients With Myelodysplastic Syndrome and Anemia
Conditions: Anemia - Leukemia - Myelodysplastic Syndromes Location: Lafayette, Indiana
- Trial of Poor Performance Status Patients (ToPPS)
Conditions: Non Small Cell Lung Cancer Location: Terra Haute, Indiana
- Vitamin D Needs of Early Adolescent Children
Conditions: Healthy Location: West Lafayette, Indiana
- Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer
Conditions: Bladder Cancer - Prostate Cancer - Transitional Cell Cancer of the Renal Pelvis and Ureter - Urethral Cancer Location: Lafayette, Indiana
- Trial of Bendamustine, Bortezomib, and Rituximab in Patients With Previously Untreated Low Grade Lymphoma
Conditions: Lymphoma Location: Terre Haute, Indiana
- Assessment of Dietary Protein Needs of Older Women
Conditions: Age Location: 700 West State St , W Lafayette, Indiana
- FOLFOXIRI Plus Panitumumab Patients With Metastatic KRAS Wild-Type Colorectal Cancer With Liver Metastases Only
Conditions: Colorectal Cancer Location: Terre Haute, Indiana
- Intravenous Palifosfamide-tris in Combination With Etoposide and Carboplatin in Patients With Malignancies
Conditions: Malignancy - Cancer - Non Small Cell Lung Cancer - Small Cell Lung Cancer - Testicular Cancer - Thymoma - Ovarian Cancer - Osteosarcoma Location: Lafayette, Indiana
- Effects of Increased, Egg-Based Protein Intake on Muscle Composition, Metabolic Health and Systemic Inflammation in Obese, Older Adults
Conditions: Muscle Composition and Muscle Size. - Metabolic Health Status. - Muscle Inflammatory Status. Location: W. Lafayette, Indiana
- Efficacy and Safety of Zoledronic Acid ( Every 4 Weeks vs. Every 12 Weeks) in Patients With Documented Bone Metastases From Bone Cancer
Conditions: Breast Cancer Location: Indianapolis, Indiana
- Efficacy and Safety of Zoledronic Acid ( Every 4 Weeks vs. Every 12 Weeks) in Patients With Documented Bone Metastases From Bone Cancer
Conditions: Breast Cancer Location: Terre Haute, Indiana
- Chemotherapy With or Without Bevacizumab in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-Small Lung Cancer That Was Removed By Surgery
Conditions: Lung Cancer Location: Lafayette, Indiana
- Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen
Conditions: Arthritis, Rheumatoid - Osteoarthritis Location: Avon, Indiana
- Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen
Conditions: Arthritis, Rheumatoid - Osteoarthritis Location: Indianapolis, Indiana
- A Pediatric Longitudinal Evaluation to Assess the Long-Term Safety of Protopic for the Treatment of Atopic Dermatitis
Conditions: Atopic Dermatitis Location: Plainfield, Indiana
- A Pediatric Longitudinal Evaluation to Assess the Long-Term Safety of Protopic for the Treatment of Atopic Dermatitis
Conditions: Atopic Dermatitis Location: West Lafayette, Indiana
- Cisplatin + Etoposide +/- Concurrent ZD6474 in Previously Untreated Extensive Stage Small Cell Lung Cancer
Conditions: Small Cell Lung Cancer Location: Lafayette, Indiana
- Cisplatin + Etoposide +/- Concurrent ZD6474 in Previously Untreated Extensive Stage Small Cell Lung Cancer
Conditions: Small Cell Lung Cancer Location: Lafayette, Indiana
- Cisplatin + Etoposide +/- Concurrent ZD6474 in Previously Untreated Extensive Stage Small Cell Lung Cancer
Conditions: Small Cell Lung Cancer Location: Terre Haute, Indiana
- Amantadine for the Treatment of Traumatic Brain Injury Irritability and Aggression: A Multi-site Study
Conditions: Brain Injury - Aggression Location: Indianapolis, Indiana
- Chronic Plaque Psoriasis (Ps) Registry
Conditions: Chronic Plaque Psoriasis Location: Plainfield, Indiana
- Phase I/II Trial of Sorafenib Plus Ixabepilone in HER2-Negative Metastatic Breast Cancer
Conditions: Metastatic Breast Cancer Location: Terre Haute, Indiana
- Neoadjuvant Sunitinib With Paclitaxel/Carboplatin in Patients With Triple-Negative Breast Cancer
Conditions: Breast Cancer Location: Terre Haute, Indiana
- A Study Evaluating Intermittent and Continuous OSI-906 and Weekly Paclitaxel in Patients With Recurrent Epithelial Ovarian Cancer (and Other Solid Tum
Conditions: Solid Tumors - Ovarian Cancer Location: Lafayette, Indiana
- Carboplatin and Paclitaxel With or Without Bevacizumab and/or Cetuximab in Treating Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer
Conditions: Lung Cancer Location: Lafayette, Indiana
- Study in Adolescents With Schizophrenia or Bipolar Disorder
Conditions: Bipolar I Disorder - Schizophrenia Location: Terre Haute, Indiana
- A Study of MM-121 Combination Therapy in Patients With Advanced Non-Small Cell Lung Cancer
Conditions: Carcinoma, Non-Small-Cell Lung Location: Lafayette, Indiana
- BNC105P in Combination With Everolimus/Following Everolimus For Progressive Metastatic Clear Cell Renal Cell Carcinoma
Conditions: Renal Cell Carcinoma Location: Lafayette, Indiana
- A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes Mellitus
Conditions: Diabetes Mellitus, Type 2 Location: Lafayette, Indiana
- PARP Inhibition for Triple Negative Breast Cancer (ER-/PR-/HER2-)With BRCA1/2 Mutations
Conditions: Breast Cancer Location: Lafayette, Indiana
- Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After
Conditions: Colorectal Cancer Location: Lafayette, Indiana
- Dose-optimization in Adolescents Aged 13-17 Diagnosed With Attention-deficit/Hyperactivity Disorder (ADHD) Using Extended-release Guanfacine HCl
Conditions: Attention-Deficit/Hyperactivity Disorder Location: Terre Haute, Indiana
- Treatment With Adenosine Diphosphate (ADP) Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome
Conditions: Acute Coronary Syndrome Location: Lafayette, Indiana
- Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combina
Conditions: Chemotherapeutic Agent Toxicity - Colorectal Cancer - Neuropathy - Neurotoxicity Location: Lafayette, Indiana
- Comparison of Lisdexamfetamine Dimesylate With Atomoxetine HCl in Attention-Deficit/Hyperactivity Disorder (ADHD) Subjects With an Inadequate Response
Conditions: Attention-Deficit/Hyperactivity Disorder Location: Terre Haute, Indiana
- Bevacizumab or Pemetrexed Disodium Alone or In Combination After Induction Therapy in Treating Patients With Advanced Non-Squamous Non-Small Cell Lung
Conditions: Lung Cancer Location: Lafayette, Indiana
- A Study of Trastuzumab Emtansine (T-DM1) Plus Pertuzumab/Pertuzumab Placebo Versus Trastuzumab [Herceptin] Plus a Taxane in Patients With Metastatic B
Conditions: Breast Cancer Location: Lafayette, Indiana
- Safety and Efficacy of BKM120 in Combination With Trastuzumab in Patients With Relapsing HER2 Overexpressing Breast Cancer Who Have Previously Failed
Conditions: Metastatic Breast Cancer - Trastuzumab - BKM120 - HER2+ Location: Lafayette, Indiana
- Evaluation of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Acute Coronary Syndrome During Treatment With AVE0010 (Lixisenatide)
Conditions: Acute Coronary Syndrome Location: Avon, Indiana
- A Safety and Tolerability Study of PCI-24781 in Subjects With Cancer
Conditions: Lymphoma - Non-Hodgkin's Lymphoma - Hodgkin Disease - Multiple Myeloma - Leukemia - Lymphocytic - Chronic Location: Lafayette, Indiana
- Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With S
Conditions: Colorectal Cancer Location: Lafayette, Indiana
- Trial of Exemestane +/- MM-121 in Postmenopausal Women With Locally Advanced or Metastatic Estrogen Receptor Positive and/or Progesterone Receptor Pos
Conditions: Her2 Negative Breast Cancer Patients Location: Lafayette, Indiana
- Study for Women With Platinum Resistant Ovarian Cancer Evaluating EC145 in Combination With Doxil® (PROCEED)
Conditions: Ovarian Cancer Location: Lafayette, Indiana
- Fludarabine, Velcade and Rituximab for Relapsed or Refractory Follicular Non-Hodgkin Lymphoma
Conditions: Lymphoma, Non-Hodgkin Location: Lafayette, Indiana
- A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional A
Conditions: Type 2 Diabetes Location: Avon, Indiana
- A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional A
Conditions: Type 2 Diabetes Location: Brownsburg, Indiana
- A Study in Patients With Rheumatoid Arthritis
Conditions: Rheumatoid Arthritis Location: Brownsburg, Indiana
- An Open Label Study for Patients With Rheumatoid Arthritis
Conditions: Rheumatoid Arthritis Location: Brownsburg, Indiana
- Bendamustine Hydrochloride and Rituximab With or Without Bortezomib Followed by Rituximab With or Without Lenalidomide in Treating Patients With High-
Conditions: Lymphoma Location: Lafayette, Indiana
- Efficacy and Safety of Asenapine Treatment for Pediatric Bipolar Disorder {P06107 Has an Extension (P05898; NCT01349907}(P06107 AM2)
Conditions: Bipolar Disorder, Pediatric Location: Terre Haute, Indiana
- A Study of Ramucirumab in Patients With Gastric, Esophageal and Gastroesophageal Cancer
Conditions: Stomach Cancer - Esophageal Cancer Location: Terre Haute, Indiana
- A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Patients With Relapsing Multiple Sclerosis
Conditions: Multiple Sclerosis, Relapsing-Remitting Location: Avon, Indiana
- A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-re
Conditions: Herpes Zoster Location: Avon, Indiana
- A Study of Carboplatin and Paclitaxel With or Without MEDI-575 in Adults With Previously Untreated, Advanced Non-Small Cell Lung Cancer
Conditions: Non-small Cell Lung Cancer Location: Lafayette, Indiana
- Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer
Conditions: Breast Cancer Location: Lafayette, Indiana
- Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer
Conditions: Cognitive/Functional Effects - Colorectal Cancer - Neurotoxicity Location: Lafayette, Indiana
- Examination of Pregabalin Access for Treatment of Indicated Pain Disorders: the ExPAND Study
Conditions: Fibromyalgia - Painful Diabetic Peripheral Neuropathy Location: Brownsburg, Indiana
- Examination of Pregabalin Access for Treatment of Indicated Pain Disorders: the ExPAND Study
Conditions: Fibromyalgia - Painful Diabetic Peripheral Neuropathy Location: Danville, Indiana
- Safety and Efficacy of BKM120 in Patients With Metastatic Non-small Cell Lung Cancer
Conditions: Non-small Cell Lung Cancer Location: Lafayette, Indiana
- A Study in Prevention of Re-emergence of Depression Symptoms
Conditions: Major Depressive Disorder Location: Lafayette, Indiana
- A Study in Prevention of Re-emergence of Depression Symptoms
Conditions: Major Depressive Disorder Location: Terre Haute, Indiana
- A 12 Week Study to Confirm the Effectiveness of 8mg of Fesoterodine Compared to 4mg of Fesoterodine
Conditions: Overactive Bladder Location: Avon, Indiana
- Evaluation of Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea® vs Placebo
Conditions: Rosacea Location: Plainfield, Indiana
- Efficacy and Safety of Flexibly Dosed BMS-820836 in the Treatment of Patients With Treatment Resistant Major Depression
Conditions: Depression Location: Lafayette, Indiana
- A 24-week Arterial Stiffness Study With Fluticasone Furoate/Vilanterol in COPD
Conditions: Pulmonary Disease, Chronic Obstructive Location: Avon, Indiana
- A 24-week Arterial Stiffness Study With Fluticasone Furoate/Vilanterol in COPD
Conditions: Pulmonary Disease, Chronic Obstructive Location: Lafayette, Indiana
- Extension Study of Asenapine {P06107 (NCT01244815)} for Pediatric Bipolar Disorder (P05898 AM2)
Conditions: Bipolar Disorder Location: Terre Haute, Indiana
- A Study of Avastin (Bevacizumab) in Combination With Standard of Care Treatment in Patients With Lung Cancer
Conditions: Non-Small Cell Lung Cancer Location: Terre Haute, Indiana
- Escalating Dose Study in Subjects With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, and Waldenstrom's Macroglobul
Conditions: B Cell Non-Hodgkin's Lymphoma - Chronic Lymphocytic Leukemia - Waldenstrom Macroglobulinemia Location: Lafayette, Indiana
- Bipolar Maintenance Study of Lurasidone Adjunctive to Lithium or Divalproex
Conditions: Bipolar I Disorder Location: Terre Haute, Indiana
- Long-term Safety and Tolerability of BMS-820836 in the Treatment of Patients With Treatment Resistant Major Depression
Conditions: Depression Location: Lafayette, Indiana
- Long-term Safety and Tolerability of BMS-820836 in the Treatment of Patients With Treatment Resistant Major Depression
Conditions: Depression Location: Terre Haute, Indiana
- Efficacy and Safety of Fixed Doses of BMS 820836 in the Treatment of Patients With Treatment Resistant Major Depression
Conditions: Depression Location: Terre Haute, Indiana
- A 6-Month Extension Study To The B2061032 Study To Evaluate The Safety, Tolerability, And Efficacy Of DVS SR In The Treatment Of Child And Adolescent
Conditions: Major Depressive Disorder Location: Terre Haute, Indiana
- A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDD
Conditions: Major Depressive Disorder Location: Terre Haute, Indiana
- Study of Bevacizumab/mFOLFOX6 Versus Bevacizumab/Folfiri With Biomarker Stratification in Patients With Previously Untreated Metastatic Colorectal Can
Conditions: Colorectal Cancer Location: Terre Haute, Indiana
- Efficacy and Safety of FLOSEAL for Hemostasis in Total Knee Arthroplasty
Conditions: Knee Replacement Surgery - Osteoarthritis Location: Mooresville, Indiana
- Efficacy and Safety of FLOSEAL for Hemostasis in Total Knee Arthroplasty
Conditions: Knee Replacement Surgery - Osteoarthritis Location: Mooresville, Indiana
- A Study Comparing RO5072759 (GA101) 1000 mg Versus 2000 mg in Patients With Previously Untreated Chronic Lymphocytic Leukemia (GAGE)
Conditions: Lymphocytic Leukemia, Chronic Location: Lafayette, Indiana
- The Plecanatide Chronic Idiopathic Constipation (CIC) Study
Conditions: Chronic Idiopathic Constipation Location: Brownsburg, Indiana
- Safety Study of MM-121 in Combination With Multiple Anticancer Therapies in Patients With Advanced Solid Tumors
Conditions: Solid Tumors Location: Lafayette, Indiana
- Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Diso
Conditions: Smoking Cessation Location: Indianaopolis, Indiana
- Efficacy and Safety of SAR292833 Administration for 4 Weeks in Patients With Chronic Peripheral Neuropathic Pain
Conditions: Neuropathic Pain Location: Indianapolis, Indiana
- Safety and Efficacy of Vilazodone in Major Depressive Disorder
Conditions: Major Depressive Disorder Location: Lafayette, Indiana
- A Study Combining mFOLFOX6 With Tivozanib or Bevacizumab in Patients With Metastatic Colorectal Cancer as First Line Therapy
Conditions: Colorectal Cancer Location: Lafayette, Indiana
- A Phase 2 Study to Evaluate the Safety and Efficacy of CTP-499 in Type 2 Diabetic Nephropathy Patients
Conditions: Type 2 Diabetes Mellitus - Chronic Kidney Disease Location: Avon, Indiana
- Short-incubation Levulan Photodynamic Therapy Versus Vehicle for Face/Scalp Actinic Keratosis (AK)
Conditions: Actinic Keratosis Location: Plainfield, Indiana
- Effects of Learning and Food Form on Intake in Humans
Conditions: Obesity Location: W. Lafayette, Indiana
- Phase 3 Papulopustular Rosacea Study
Conditions: Papulopustular Rosacea (PPR) Location: Plainfield, Indiana
- A Study of Onartuzumab (MetMAb) in Combination With Bevacizumab (Avastin) Plus Platinum And Paclitaxel or With Pemetrexed Plus Platinum in Patients Wi
Conditions: Non-Small Cell Lung Cancer Location: Indianapolis, Indiana
- Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes Mellitus on Basal Plus Mealtime Insulin
Conditions: Type 2 Diabetes Mellitus Location: Avon, Indiana
- Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes Mellitus on Basal Plus Mealtime Insulin
Conditions: Type 2 Diabetes Mellitus Location: Avon, Indiana
- Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes Mellitus on Basal Plus Mealtime Insulin
Conditions: Type 2 Diabetes Mellitus Location: Avon, Indiana
- Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes Mellitus on Basal Plus Mealtime Insulin
Conditions: Type 2 Diabetes Mellitus Location: Avon, Indiana
- Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes Mellitus on Basal Plus Mealtime Insulin
Conditions: Type 2 Diabetes Mellitus Location: Avon, Indiana
- Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes on Basal Insulin With Oral Antidiabetic Therapy
Conditions: Type 2 Diabetes Mellitus Location: Avon, Indiana
- Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes on Basal Insulin With Oral Antidiabetic Therapy
Conditions: Type 2 Diabetes Mellitus Location: Avon, Indiana
- Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes on Basal Insulin With Oral Antidiabetic Therapy
Conditions: Type 2 Diabetes Mellitus Location: Avon, Indiana
- Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes on Basal Insulin With Oral Antidiabetic Therapy
Conditions: Type 2 Diabetes Mellitus Location: Avon, Indiana
- Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes on Basal Insulin With Oral Antidiabetic Therapy
Conditions: Type 2 Diabetes Mellitus Location: Avon, Indiana
- A Therapeutic Equivalence Study of Two Metronidazole 1%Topical Gel Treatments for Patients With Rosacea
Conditions: Rosacea Location: Plainfield, Indiana
- A Study of Onartuzumab (MetMAb) Versus Placebo in Combination With Paclitaxel Plus Platinum in Patients With Squamous Non-Small Cell Lung Cancer
Conditions: Non-Small Cell Lung Cancer Location: Indianapolis, Indiana
- Safety Study of the Drug MM-151 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment
Conditions: Advanced Solid Tumors Location: Lafayette, Indiana
- Etanercept Treatment in Subjects With Moderate to Severe Plaque Psoriasis Who Lost Response to Adalimumab
Conditions: Psoriasis Location: Plainfield, Indiana
- Docetaxel and Cyclophosphamide Compared to Anthracycline-Based Chemotherapy in Treating Women With HER2-Negative Breast Cancer
Conditions: Breast Cancer Location: Lafayette, Indiana
- Free Fatty Acids: Threshold Repeatability Study
Conditions: Taste, Non-esterified Fatty Acids Location: West Lafayette, Indiana
- A Trial Comparing the Efficacy, Patient-reported Outcomes and Safety of Insulin Degludec 200 U/mL vs Insulin Glargine in Subjects With Type 2 Diabetes
Conditions: Diabetes - Diabetes Mellitus, Type 2 Location: Avon, Indiana
- A Study of Lebrikizumab in Patients With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and A Second Controller Medication (VERSE)
Conditions: Asthma Location: Lafayette, Indiana
- Study of a Melanoma Vaccine in Stage IIb, IIc, and III Melanoma Patients
Conditions: Melanoma Location: Indianapolis, Indiana
|