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Snoring Clinical Trials, Diagnosis, and Treatment
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Snoring

Snoring is the vibration of respiratory structures and the resulting sound, due to obstructed air movement during breathing while sleeping. The sound may be soft or loud and unpleasant. The structures are usually the uvula and soft palate. The irregular airflow is caused by a blockage, due to causes including:
  • Throat weakness causing the throat to close during sleep
  • Mispositioned jaw, often caused by tension in muscles
  • Fat gathering in and around the throat
  • Obstruction in the nasal passageway
Statistics on snoring are often contradictory, but at least 30% of adults and perhaps as many as 50% of people in some demographics snore. One survey of 5,713 Italian residents identified habitual snoring in 24% of men and 13.8% of women, rising to 60% of men and 40% of women aged 60 to 65 years; this suggests an increased susceptibility to snoring as age increases.

Snoring is usually an involuntary act, but may also be produced voluntarily.

According to Dr. William C Dement, of the Stanford Sleep Center, anyone who snores and has daytime drowsiness should be evaluated for sleep disorders.

Current Research

For current research articles click - here

Impacts

Snoring is known to cause sleep deprivation to both the snorer and those who hear him/her, as well as knock-on effects: daytime drowsiness, irritability, lack of focus, decreased libido. It has also been suggested that it can cause significant psychological and social damage to sufferers.

Armstrong et al. at the Royal Infirmary of Edinburgh found that snoring strains interpersonal relationships, and concerns for its effects were often voiced above the medical malady. Patients also lamented the social embarrassment arising from complaints when they sleep outside their homes. Both business and holiday arrangements can be detrimentally affected.

While snoring may popularly be seen in some circles as a minor affliction, snorers can suffer severe impairment of lifestyle. The between-subjects trial by Armstrong et al. discovered a statistically significant improvement in marital relations after snoring was surgically corrected. This was confirmed by evidence from Gall et al., Cartwright and Knight and Fitzpatrick et al.

Diagnosis

Ordinarily, snoring is recognised by a friend or partner who observes the patient sleeping. Besides the 'noise' of snoring, more complex conditions such as sleep apnea can be consistent with the symptom of snoring. A sleep study can identify such issues. Patients can also assess their own condition to determine the likelihood of such problems based on the severity of their sleeping disorder.

Treatment

Almost all treatment for snoring revolves around clearing the blockage in the breathing passage. This is the reason snorers are advised to lose weight (to stop fat from pressing on the throat), to stop smoking (smoking weakens and clogs the throat), and to sleep on their side (to prevent the tongue from blocking the throat).

Other forms of treatment are also available:

Dental Appliances

Specially made dental appliances such as a mandibular advancement splint, which advance the lower jaw slightly, and thereby pull the tongue forward, are a preferred mode of treatment for social snoring. Typically, a dentist specializing in sleep apnea dentistry is consulted. Such appliances have been proven to be effective in reducing snoring and sleep apnea, however side effects include the possibility that a patient's bite could be altered. Typical costs for such appliances would be between USD1000 to USD3000.

"Do it yourself" dental appliances are also available, which cost around USD50 to USD200. They are usually made from an EVA polymer, and are similar in appearance to protective mouth-guards worn for sports. Like the professionally fitted devices, they hold the lower jaw forward to move the tongue forward. One disadvantage these cheaper devices have over the professionally fitted devices is the difficulty in setting up the correct jaw position. An over-advanced jaw results in jaw joint pain, whilst an under-advanced jaw produces no therapeutic effect. The professionally fitted devices generally incorporate an adjustment mechanism so that jaw advancement can be easily increased or decreased after fitting. To adjust the "do it yourself" appliances it is necessary to reheat them and mold them again in the desired new position. Alternatively, given the low cost, a new appliance can be used to hold the jaw in the new position.

These "do it yourself" devices can be purchased at pharmacies in most countries (except the U.S.), or online (anywhere - though not legally in U.S.). In the U.S., the devices are considered class 2 medical devices and cannot be legally sold without a prescription. The FDA (Food and Drug Administration) has never made their reasons for this decision clear. In Australia, manufacturers can obtain approval from the TGA (Therapeutic Goods Administration) allowing the devices to be sold via normal retail channels, without the involvement of a doctor.

Possible side effects of these devices include Temporomandibular joint disorder (TMJD). TMJD is an inflammation of the temperomandibular joint (jaw joint) which can be very painful and is sometimes, although very rarely, irreversible. There is no reliable way of knowing whether a person is at risk for TMJ before they start using a dental appliance.

Positive Airway Pressure

A Continuous Positive Airway Pressure (CPAP) machine is often used to control sleep apnea and the snoring associated with it. To keep the airway open, a shoebox-sized device pumps a controlled stream of air through a flexible hose to a mask worn over the nose, mouth, or both.

Surgery

Surgery is also available to correct social snoring. Some procedures, such as uvulopalatopharyngoplasty attempt to widen the airway by removing tissues in the back of the throat including the uvula and pharynx. These surgeries are quite invasive, and there are risks of adverse side effects. The most dangerous risk is that enough scar tissue could form within the throat as a result of the incisions to make the airway more narrow than it was prior to surgery, diminishing the airspace in the velopharnyx. Scarring is an individual trait. It is difficult for a surgeon to predict how much a person might be predisposed to scarring. Some patients have reported that they developed severe sleep apnea as a result of damage to their airway caused by pharnygeal surgeries. At the present time, the American Medical Association does not approve of the use of lasers to perform operations on the pharnyx or uvula.

Radiofrequency ablation (RFA) is a relatively new surgical treatment for snoring. This treatment applies radiofrequency energy and heat (between 77ºC to 85ºC) to the soft tissue at the back of the throat, such as the soft palate and uvula, causing scarring of the tissue beneath the skin. After healing, this results in stiffening of the treated area. The procedure takes less than one hour, is usually performed on an outpatient basis, and usually requires several treatment sessions. Discomfort and pain is usually minimal. Radiofrequency ablation is frequently effective in reducing the severity of snoring, but, often does not completely eliminate snoring.

Positioning

Snoring can be reduced by changing position on the bed; Sleeping on the side is a possible solution, to avoid rolling back it is possible to place a pillow or a "ball" on the back; raising the head is also another option, useful both while lying on the back or for supporting the head while lying on the side.

Other Treatments

Devices such as nose clips can dilate the nostrils and other devices can alter jaw mechanics to keep the jaw in an optimum position. Different aids and practices may work for different people. According to the British Medical Journal, playing the didgeridoo can also help, as it increases muscle usage in the throat. However, snoring is a recognized medical problem and people who snore should always seek professional medical advice before relying on techniques which may mask symptoms (i.e. snoring) but not treat the underlying condition.

A large number of product manufacturers and vendors offer "non-surgical" snoring treatments which are promoted as "cures" or "treatment" for snoring. Some examples include 'throat lubricants', moulded pillows, accupressure devices and herbal sprays. Such products are frequently offered for sale on the Internet and are generally attractive as their low price (and the potential for avoiding a trip to the doctor) encourage people to "have a go" and try them to see if they work. Given the complexity of snoring, in general, such 'cures' are of little benefit.

However, snoring may be helped by using the Buteyko Method as Buteyko has been shown to reduce the volume of air automatically breathed by 31% within three months of starting a course. Since snoring is the sound of a person breathing forcefully through narrowed airways, when breathing is done with less force, as is likely to happen by using the Buteyko Method, then the snoring sound is likely to decrease.


(adapted from Wikipedia, the free encyclopedia http://en.wikipedia.org/wiki/Snoring)





Findings From Current Research

Obstructive Sleep Apnea in Older Adults

Authors: Norman D, Loredo JS.

Division of Pulmonary and Critical Care Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, MC 0804, San Diego, CA 92093-0804, USA.

The "typical" presentation of obstructive sleep apnea (OSA) is chronic loud snoring and excessive daytime sleepiness in middle-aged obese men. OSA can result in increased risk for cardiovascular morbidity and mortality. The diagnostic features of OSA in older adults are similar to those in younger adults; however, the older adult may be less likely to seek medical attention or have the sleep disorders recognized because symptoms of snoring, sleepiness, fatigue, nocturia, unintentional napping, and cognitive dysfunction may be ascribed to the aging process itself or to other disorders. This article reviews the basic terminology and pathophysiology of sleep-disordered breathing, discusses why OSA may be even more prevalent in older adults than in the middle-aged group, and reviews similarities and differences between the two groups in the manifestations, consequences, and treatments of OSA.

Journal: Clin Geriatr Med. 2008 Feb;24(1):151-65.
Adapted from PubMed; click here to access full journal article.




Prevalence of Recurrent Otitis Media in Habitually Snoring School-Aged Children

Authors: Gozal D, Kheirandish-Gozal L, Capdevila OS, Dayyat E, Kheirandish E.

Division of Pediatric Sleep Medicine and Kosair Children’s Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA.

INTRODUCTION: The pathophysiology of obstructive sleep apnea (OSA) and recurrent otitis media (ROM) is intimately associated with the presence of adenotonsillar hypertrophy in children. However, it remains unclear whether habitually snoring children have a higher prevalence of ROM and whether they require tympanostomy tube placement more frequently. METHODS: Questionnaires collected from parental surveys of 5- to 7-year-old children attending the public schools in Louisville, KY were retrospectively reviewed for the presence of habitual snoring (HS), ROM, and the need for tympanostomy tube insertion. RESULTS: There were 16,321 surveys with complete datasets (51.2% boys; 18.6% African American (AA) with a mean age of 6.2+/-0.7 years). Of these children, 1844 (11.3%) were HS (53% boys; 25.9% AA); and, of these, 827 HS had also a positive history of ROM (44.8%) with a slight predominance in males (55%). In addition, 636 of these children underwent placement of tympanostomy tubes (i.e., 34.4% of all HS and 76.9% of ROM). Among the 14,477 non-snoring children (NS), ROM was reported in 4247 NS children (29.3%; p<0.000001; odds ratio [OR]: 1.95; confidence interval [CI]: 1.77-2.16) of which 57.6% were boys, and 1969 NS with ROM underwent tympanostomy tube placement (i.e., 46.3% of those with ROM and 13.6% of all non-snoring children). Thus, the risk for tympanostomy tube placement was also greater among HS compared to NS children (p<0.00001; OR: 2.19; CI: 1.98-2.43). CONCLUSIONS: Habitual snoring is associated with a significant increase in the prevalence of recurrent otitis media and the need for tympanostomy tube placement. Further studies aiming to assess the prevalence of obstructive sleep apnea among children with ROM are needed.

Journal: Sleep Med. 2007 Oct 5
Adapted from PubMed; click here to access full journal article.




Pre-Eclampsia and Nasal CPAP: Part 2. Hypertension During Pregnancy, Chronic Snoring, and Early Nasal CPAP Intervention

Authors: Poyares D, Guilleminault C, Hachul H, Fujita L, Takaoka S, Tufik S, Sass N.

Federal University of Sao Paulo Sleep Disorders Center, Brazil; Stanford University Sleep Medicine Program, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA.

OBJECTIVES: To evaluate the potential benefit of nasal continuous positive airway pressure (CPAP) administration in pregnant women recognized to have hypertension early in pregnancy. METHODS: This is a randomized study comparing the addition of nasal CPAP treatment to standard prenatal care to standard prenatal care alone in hypertensive women treated with alpha-methyl dopa during early pregnancy. Pregnant women with hypertension were recruited by their obstetricians and completed baseline sleep questionnaires and visual analogue scales on snoring and sleepiness. Subjects were then randomized to receive either CPAP with standard prenatal care (treatment group) or standard prenatal care alone (control group) with routine obstetric follow-up. Nocturnal polysomnography was performed in all patients randomized to the treatment group for initial CPAP titration. Periodic assessment of blood pressure control and CPAP compliance was performed by the same specialist at each scheduled follow-up visit. RESULTS: In the control group (n=9), a progressive rise in blood pressure with a corresponding increase in alpha-methyl dopa doses was observed, beginning at the sixth month of pregnancy. There was also an increase in the number of non-scheduled post-natal visits during the first postpartum month. Pre-eclampsia occurred in one subject; the remaining eight patients had normal pregnancies and infant deliveries. In the treatment group (n=7), blood pressure was noted to decrease significantly as compared to the control group with associated decreases in doses of antihypertensive medications at six months of gestation. All treated patients experienced uncomplicated pregnancies and delivered infants with higher APGAR scores at one minute post-delivery compared to those of controls. CONCLUSION: In pregnant women with hypertension and chronic snoring, nasal CPAP use during the first eight weeks of pregnancy combined with standard prenatal care is associated with better blood pressure control and improved pregnancy outcomes.

Journal: Sleep Med. 2007 Jul 17
Adapted from PubMed; click here to access full journal article.




Prosthetic Management of Pharyngeal Flap-Related Snoring

Authors: Williams WN, Turner GT, Lewis K, Pegoraro-Krook MI, Dutka-Souza JC.

University of Florida Craniofacial Center, College of Dentistry, Gainesville 32610, USA, and the University of São Paulo's Hospital for Rehabilitation of Craniofacial Anomalies, Bauru, Brazil. williams@dental.ufl.edu

OBJECTIVE: The obturating pharyngeal flap used in correcting velopharyngeal insufficiency has been implicated in creating difficulty in nasal breathing for some patients and/or in causing hyponasal speech, obstructive sleep apnea, and snoring. This is a case report of an individually designed removable prosthesis that positions an acrylic tube through each port lateral to the pharyngeal flap, with the goal of preventing the collapse of the ports during sleep and the consequent snoring. DESIGN: The acrylic tubes maintain an opening through both lateral ports preventing the soft tissues of the lateral walls from vibrating against the pharyngeal flap (causing the snoring sound) and allowing nasal breathing. RESULTS: The acrylic tubes effectively eliminated the patient's problem of snoring. CONCLUSIONS: This case study demonstrates that snoring associated with a pharyngeal flap can be controlled prosthetically by maintaining an opening through the two lateral ports, preventing the soft tissues of the walls of the lateral ports from vibrating against the flap.

Journal: Cleft Palate Craniofac J. 2007 Jul;44(4):418-20.
Adapted from PubMed; click here to access full journal article.




Additional Palatal Implants for Refractory Snoring

Authors: Catalano P, Goh YH, Romanow J.

Lahey Clinic, Burlington, MA 01805, USA. peter.j.catalano@lahey.org

OBJECTIVE: To evaluate safety and efficacy of additional palatal implants for snoring treatment. STUDY DESIGN AND SETTING: A prospective case series at two clinical sites in an office setting. Patients who did not have an acceptable reduction in snoring intensity after an initial 3 implant procedure received additional implants. Bed partners rated snoring intensity on a 10 cm visual analog scale (VAS) at baseline and 90 days post procedure. RESULTS: Snoring intensity VAS decreased significantly from 6.4 +/- 2.3 to 4.6 +/- 2.9 (P < 0.01) for patients who received an additional fourth implant, and to 4.1 +/- 2.8 after the 5th implant (P<0.01). Epworth sleepiness scale scores also decreased significantly for patients who received additional fourth or fifth implants. There were no adverse events. CONCLUSIONS: Additional palatal implants for snoring treatment were safe and effective in this case series. SIGNIFICANCE: Additional implants may offer relief for snorers not responding to the initial 3 implant procedure.

Journal: Otolaryngol Head Neck Surg. 2007 Jul;137(1):105-9.
Adapted from PubMed; click here to access full journal article.




Snoring: A Critical Analysis of Current Treatment Modalities. Does Anything Really Work?

Authors: Savage CR, Steward DL.

Department of Otolaryngology, Head and Neck Surgery, University of Cincinnati, Cincinnati, Ohio, USA.

PURPOSE OF REVIEW: To determine the current options available for the treatment of snoring in the symptomatic patient, as this can be troublesome not only for the patient, but also the patient's bed partner. These include both surgical and non-surgical measures. RECENT FINDINGS: The main themes that will be addressed include over-the-counter snoring aids, oral appliances, and surgical options. Surgical options include uvulopalatopharyngoplasty, laser-assisted uvulopalatoplasty, radiofrequency thermal ablation therapy, injection snoreplasty, and palatal implants. SUMMARY: There are many alternatives available to treat snoring. None of these methods are without their negative aspects, therefore there is still a great need for further research and long-term follow-up studies to determine the best method. The final consensus of this review is that surgical options yield the best results, but these are often surgeon dependent, and none are free of relapses in snoring. Some options are also thought to offer several advantages, including less peri-operative pain and recovery time, less expense, and the ability to be performed in the office. The palatal implant system and radiofrequency thermal ablation appear to have relatively good outcomes, with little postoperative pain and relatively self-limited complications. They also have the convenience of an in-office procedure and less expense.

Journal: Curr Opin Otolaryngol Head Neck Surg. 2007 Jun;15(3):177-9.
Adapted from PubMed; click here to access full journal article.




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