RATIONALE: Lorazepam, diphenhydramine hydrochloride, and haloperidol gel, when absorbed into
the skin, may be an effective treatment for nausea and vomiting.PURPOSE: This clinical trial
studies lorazepam, diphenhydramine hydrochloride, and haloperidol gel in healthy volunteers.
OBJECTIVES:I. To study the absorption of the three components in the topical ABH gel in 10
healthy volunteers, and determine if there are any adverse effects. OUTLINE: Patients apply
lorazepam, diphenhydramine hydrochloride, and haloperidol gel topically over 2 minutes. After
completion of study treatment, patients are followed up for 5 hours.
- Completed a medical screening questionnaire
- English speaking
- No allergies to the drugs
- Able to complete the forms
- If a woman of childbearing age, agree to use contraception
- History of substance abuse, psychiatric disorder, acquired brain injury, the
possibility of pregnancy (not using birth control, and of child bearing age)
- Use of any medication that would contraindicate benzodiazepine administration
- Pregnant or nursing