View Clinical Trial (Medical Research Study)
The Evaluation of Women With Menstrually Regulated Mood and Behavioral Disorders
| City: |
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Bethesda |
| State: |
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Maryland |
| Zip Code: |
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20892 |
| Conditions: |
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PMS - Premenstrual Mood Disorder - PMDD - Depression |
| Purpose: |
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The purpose of this study is to identify and describe the symptoms of premenstrual syndrome
(PMS).
Women who experience PMS symptoms will complete clinical interviews, self-rating scales, and
evaluations of mood and endocrine function. A subgroup of women with severe PMS
(Premenstrual Dysphoric Disorder or PMDD) will be offered additional research studies that
focus on: 1) identifying the endocrine changes that may be responsible for changes in mood
and behavior during the premenstrual period, 2) evaluating treatments for PMS symptoms,
and/or 3) identifying genetic factors in women with and without PMS. Women with recurrent
brief depression will also be recruited to serve as a comparison group.
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| Study Summary: |
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The relevance of changes in ovarian steroids in the pathophysiology of menstrually-regulated
mood disorders (MRMD [the term Premenstrual Dysphoria (PMD) will be employed in the text
instead of MRMD] remains to be fully characterized. The purpose of this protocol is to
allow for the careful screening of patients and healthy volunteers for participation in
research protocols that examine the role of gonadal steroids in PMD and for the collection
of natural history data. Women in this protocol will undergo an evaluation which may
include: a psychiatric interview; a diagnostic interview; daily symptom rating scales; a
medical history; a physical exam; blood and urine laboratory evaluation; and a request for
medical records. The data collected may also be linked with data from other PMD protocols
(e.g., DNA, psychophysiology tests, treatment studies, etc.) for the purposes of better
understanding the diagnosis, pathophysiology, and treatment response of women with PMD.
Upon conclusion of the evaluation process, subjects will either be offered participation in
a research protocol and will sign the appropriate informed consent, or will be considered
not appropriate for participation in research and will be referred back into the community.
Finally, we wish to identify a group of women with recurrent brief depression, who will
serve as an additional control group for the patients with menstrual cycle-related mood
disorders. This protocol, then, serves as a screening and evaluation protocol to recruit
subjects who are characterized with standard measures in this protocol and then offered
participation in related studies.
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| Criteria: |
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- INCLUSION CRITERIA:
The subjects of this study will be women who meet the following criteria:
- history within the last two years of at least six months with menstrually-related
mood or behavioral disturbances of at least moderate severity - that is, disturbances
that are distinct in appearance and associated with a notable degree of subjective
distress;
- a 30% increase in mean negative mood ratings (relative to the range of the scale
employed) in the premenstrual week compared with the week following the end of menses
in at least two of three cycles;
- age 18 to 50;
- not pregnant and in good medical health;
- regular menses.
Subjects who do not meet the criteria listed above but who do meet diagnostic criteria for
recurrent brief depression will also be studied. The criteria for recurrent brief
depression include the following:
- dysphoric mood or loss of interest or pleasure;
- duration less than two weeks;
- four of the following symptoms: poor appetite or significant weight loss (when not
dieting) or increased appetite or significant weight gain; insomnia or hypersomnia;
psychomotor agitation or retardation; loss of interest or pleasure in usual
activities, or decrease in sexual drive; loss of energy; fatigue; feelings of
worthlessness, self-reproach, or excessive or inappropriate guilt; diminished ability
to think or concentrate, slowed thinking, or indecisiveness;
- impairment in usual occupational activities;
- at least one-two episodes per month over one year.
Age-matched women without mood and behavioral disorders will be recruited.
EXCLUSION CRITERIA:
Subjects should have no general medical illness that is primary (i.e., appears to be
causing the mood disorder);
Current alcohol or substance use or dependence (excluding nicotine) of sufficient
magnitude to require independent, concurrent treatment intervention (e.g., antabuse or
opiate treatment, but not including self-help groups).
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| NCT ID: |
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NCT00001177 |
| Primary Contact: |
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Principal Investigator
Peter J Schmidt, M.D.
National Institute of Mental Health (NIMH)
Peter J Schmidt, M.D.
Phone: (301) 496-6120
Email: peterschmidt@mail.nih.gov
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| Backup Contact: |
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N/A |
| Location Contact: |
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Bethesda, Maryland 20892
United States
For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)
Phone: 800-411-1222
Email: prpl@mail.cc.nih.gov
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 19, 2013 |
| Modifications to this listing: |
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