View Clinical Trial (Medical Research Study)
Studies of Molecular Genetics of Insulin Secretion, Insulin Action, and Diabetes Mellitus
| City: |
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Bethesda |
| State: |
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Maryland |
| Zip Code: |
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20892 |
| Conditions: |
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Diabetes Mellitus - Insulin Resistance |
| Purpose: |
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The study will allow researchers to obtain blood, plasma, DNA, and RNA for genetic studies
of insulin. There will be a focus on the causes of insulin resistance and diabetes
mellitus. Insulin is a hormone found in the body that controls the level of sugar in the
blood. Insulin resistance refers to conditions like diabetes when insulin does not work
properly. In this study researchers would like to compare patients with diabetes and other
forms of insulin resistance to normal individuals. The study will investigate how insulin
attaches to cells.
Researchers will take 4 to 6 ounces (100-150 ml) of blood from adult patients and may
request up to 12 ounces (one unit) of blood if necessary. Skin samples may be taken for a
biopsy if further genetic testing is necessary. In addition some patients may be asked not
to eat for up to 72 hours prior to testing.
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| Study Summary: |
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The purpose of this protocol is to enable us to obtain adequate blood or tissue samples to
study the molecular mechanisms underlying various causes of insulin resistance and diabetes
mellitus. Patients with evidence for insulin resistance will be eligible to participate in
this study. We particularly focus our study on the following four groups of patients:
1. Patients with various syndromes of lipoatrophy, lipodystrophy
2. Patients with mutations on the insulin receptor gene
3. Patients with autoantibodies to the insulin receptor
4. Patients with severe forms of insulin resistance
In addition, patients displaying unusual phenotypic features (i.e. presence of acanthosis
nigricans) in association with hyperinsulinemia (i.e. fasting insulin levels greater than 30
microU/ml) or clinical diabetes mellitus may be eligible to be studied at NIH.
The work-up will include all or some of the following studies:
Routine biochemical profile
Fasting insulin, glucose, HbA1c, lipid profile, lipoprotein profile, IGF-1 level, leptin
level
A panel of hormone levels: thyroid and sex hormones, pituitary hormones, adrenal hormones
and growth hormone
Blood samples for genetic studies
Oral glucose tolerance test
In vitro insulin or IGF-1 binding
Autoantibodies to the insulin receptor if Type B insulin resistance is suspected
The total quantity of blood collected is within the approved NIH guidelines appropriate to
the individual's age and size. In addition, some subjects may undergo skin biopsy for the
establishment of fibroblast cell lines. Some adult patients with lipoatrophy and
lipodystrophy may be asked to undergo a muscle biopsy to broaden the molecular studies.
Liver biopsies may be performed if clinically indicated in patients with lipoatrophy and
lipodystrophy. DEXA analyses and anthropometric measurements are performed when medically
indicated during the diagnosis and evaluation to correlate markers of insulin resistance
with parameters of whole body composition.
In a novel component of the study, we aim to study the biochemical and molecular changes
that occur with standard therapies (such as high dose insulin, continuous insulin therapy,
metformin, and TZD's) used for the treatment of insulin resistance and diabetes.
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| Criteria: |
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- INCLUSION/EXCLUSION CRITERIA
At least one of the following is required:
Hyperinsulinemia (i.e. greater than 30 microgramsU/mL).
Clinical presence of diabetes.
Phenotypic features suggesting a defect in glucose/lipid metabolism:
Acanthosis nigricans;
Lipoatrophy/lipodystrophy;
Lipomatosis;
Xanthomata;
Fatty liver
Family members of patients with known disease states of insulin action.
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| NCT ID: |
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NCT00001987 |
| Primary Contact: |
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Principal Investigator
Phillip Gorden, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Elaine K Cochran, C.R.N.P.
Phone: (301) 496-2718
Email: elainec@intra.niddk.nih.gov
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| Backup Contact: |
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Email: philg@mail.nih.gov
Phillip Gorden, M.D.
Phone: (301) 402-7340
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| Location Contact: |
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Bethesda, Maryland 20892
United States
For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)
Phone: 800-411-1222
Email: prpl@mail.cc.nih.gov
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 22, 2013 |
| Modifications to this listing: |
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