View Clinical Trial (Medical Research Study)
Endocrine Studies in Health and Disease
| City: |
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Bethesda |
| State: |
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Maryland |
| Zip Code: |
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20892 |
| Conditions: |
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Endocrine Diseases |
| Purpose: |
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This study will evaluate healthy normal volunteers and patients with a variety of endocrine
disorders to 1) learn more about conditions that affect the endocrine glands (glands that
secrete hormones) and 2) train physicians in endocrinology.
Patients with endocrine-related conditions and healthy volunteers of all ages may be
eligible for this study.
All participants will have a physical examination medical and history. They may be required
to provide blood, saliva or urine samples and undergo ultrasound (using sound waves) or
magnetic resonance (using a magnetic field) imaging to visualize internal body structures.
Some healthy adult volunteers will have hormone-stimulating tests to assess endocrine
function. These tests measure blood hormone levels before and after injection of a
synthetic form of a hormone. A device called a heparin lock, through which the hormone is
injected and the blood samples are collected, is placed in a vein in the arm or hand. Blood
samples are drawn before the hormone is injected and at various intervals after the
injection to measure levels of the hormone. These tests, which last from 1 to 3 hours, may
include the following:
1. CRH stimulation test-corticotropin-releasing hormone is given to test pituitary and
adrenal gland function
2. ACTH stimulation test-adrenocorticotrophic hormone is given to test adrenal gland
function
3. LHRH stimulation test-luteinizing hormone-releasing hormone is given to test pituitary
gland function
4. TRH stimulation test-thyroid-releasing hormone is given to test pituitary and thyroid
gland function
5. GHRH stimulation test-growth hormone releasing hormone is given to measure growth
hormone levels.
An oral glucose tolerance test, which is similar to the stimulation tests, may also be done
to measure blood glucose (sugar) and insulin levels after drinking a sugary liquid.
Healthy volunteers and patients with a hereditary endocrine disorder and their family
members may also be asked to provide a blood sample for genetic studies of inherited
endocrine disorders. Patients with endocrine-related disorders may be offered medical or
surgical treatment for their disorder.
AcAccess http://turners.nichd.nih.gov/ for additional study publications.
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| Study Summary: |
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This protocol is designed to allow endocrine-related evaluations of healthy subjects and
patients with a variety of endocrine disorders. Healthy subjects may be studied to obtain
normative data for endocrine tests involving blood, urine, saliva, ultrasound and magnetic
resonance examinations. If not eligible for a specific NICHD research protocol, patients
with endocrine-related conditions may be evaluated under the auspices of this protocol to
advance the clinical skills of physicians participating in NICHD clinical research and
training programs, and to provide stimuli for new clinical research initiatives. Standard,
medically-indicated laboratory or radiological studies may be performed to confirm a
diagnosis or to aid in the management of the patient. In some cases, the patient will
receive medical or surgical treatment for their disorder, according to current clinical
practice. The overall purpose of endocrine evaluations under this protocol is to support
our clinical training and research missions.
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| Criteria: |
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- INCLUSION CRITERIA
Healthy subjects and patients with endocrine-related conditions of all ages are eligible
for this protocol. The actual selection of patients most appropriate for clinical
training needs will be made by protocol investigators.
Subjects with disabilities are not formally excluded from the study unless the disability
would specifically prevent participation. If a subject with cognitive impairment wishes
to participate, there must be available a family member or other qualified individual
holding a durable power of attorney who is able to guide the impaired subject's
participation and be an advocate for their interests. This participation is limited to
the non-research, clinical training arm of the study.
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| NCT ID: |
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NCT00006073 |
| Primary Contact: |
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Principal Investigator
Margaret F Keil, C.R.N.P.
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Margaret F Keil, C.R.N.P.
Phone: (301) 435-3391
Email: keilm@cc1.nichd.nih.gov
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| Backup Contact: |
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N/A |
| Location Contact: |
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Bethesda, Maryland 20892
United States
For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)
Phone: 800-411-1222
Email: prpl@mail.cc.nih.gov
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 21, 2013 |
| Modifications to this listing: |
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