View Clinical Trial (Medical Research Study)
Scleroderma Family Registry and DNA Repository
| City: |
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Houston |
| State: |
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Texas |
| Zip Code: |
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77030 |
| Conditions: |
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Systemic Sclerosis - Scleroderma |
| Purpose: |
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Scleroderma is likely caused by a combination of factors, including an external trigger
(infection or other exposure) and a genetic predisposition. The Scleroderma Registry will
conduct genetic analyses for disease-related genes in patients with scleroderma and their
family members (parents, brothers, and sisters).
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| Study Summary: |
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Scleroderma refers to a group of diseases that involve the abnormal growth of connective
tissue, which supports the skin and internal organs. Scleroderma can affect the skin, making
it hard and tight; it can also damage the blood vessels and internal organs such as the
heart, lungs, and kidneys. Estimates for the number of people in the United States with the
systemic (body-wide) form of scleroderma range from 40,000 to 165,000. The number of people
with all scleroderma-related disorders is between 250,000 and 992,500.
Researchers believe that several factors interact to produce scleroderma, including abnormal
immune activity, potential environmental triggers, and genetic makeup. Scleroderma is not
passed on from parents to child, but certain genes may make a person more likely to develop
the disease. The goals of this project are to identify the genes that influence disease
susceptibility and expression in systemic scleroderma and to establish a repository of DNA,
plasma, and serum samples from single case scleroderma families, multicase families, and
healthy unrelated volunteers for the use of researchers interested in studying this disease.
Participants in the Registry will have a phone interview regarding disease characteristics
and family history. Participants will be sent a blood kit to get a blood sample drawn
locally for shipment to the Registry lab. Blood samples will be made available (anonymously)
for studies by researchers around the country. In some cases, participants will be asked to
sign a release of medical information so that medical records can be obtained to verify the
diagnosis.
As of May 2009, this study is no longer enrolling family members.
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| Criteria: |
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Inclusion Criteria
- Diagnosis of systemic sclerosis or family members of patients with systemic sclerosis
Or
- Healthy volunteer with no autoimmune disease and without a first-degree relative with
a systemic autoimmune disease
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| NCT ID: |
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NCT00074568 |
| Primary Contact: |
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Principal Investigator
Maureen D. Mayes, MD, MPH
The University of Texas Health Science Center, Houston
Jason Anderson
Phone: 713-500-7196
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| Backup Contact: |
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N/A |
| Location Contact: |
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Houston, Texas 77030
United States
Jason Anderson
Phone: 713-500-7196
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 20, 2013 |
| Modifications to this listing: |
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