ADHD Symptoms in Autism: Cognition, Behavior, Treatment
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| City: |
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Houston |
| State: |
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Texas |
| Zip Code: |
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77054 |
| Conditions: |
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Autism - Attention Deficit Disorder With Hyperactivity |
| Purpose: |
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This study examined the cognitive and behavioral differences in children who have an autism
spectrum disorder (ASD) with or without additional symptoms of ADHD. The study also examined
the effectiveness of a range of doses of methylphenidate in improving cognitive and
behavioral outcomes in children with both ASD and ADHD.
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| Study Summary: |
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Attention Deficit Hyperactivity Disorder (ADHD) is a major comorbid psychiatric disorder in
children with Autism Spectrum Disorders (ASD) that significantly undermines behavioral,
social, and emotional adjustment. Although the Diagnostic and Statistical Manual of Mental
Disorders (DSM-IV) does not specifically allow for a comorbid diagnosis of ADHD with ASD,
many children with an ASD manifest symptoms of ADHD and are treated for it with stimulants
or other medication. The few studies on ADHD in ASD have not consistently established its
cognitive and behavioral manifestations, or the optimal parameters for treatment. The
proposed project will address these issues through studies of cognitive and behavioral
functioning in children with ASD, with and without ADHD, and through a study of medication
treatment of ADHD symptoms in autism.
Participants between the ages of 7 to 12 with an autism spectrum disorder participated in
the initial phase of the study to examine the nature and effects of ADHD symptoms on
behavioral and cognitive functioning. Participants underwent an initial psychological
testing session that included standardized measures of intellectual, adaptive behavior,
language, behavioral, and emotional functioning, along with standardized diagnostic measures
to confirm their diagnoses of ASD and/or ADHD (Visit 1). Children with intelligence
quotients (IQs) below 50 or greater than 130 or with major sensory, motor, neurological,
genetic, or psychiatric disorders that may interfere with testing were be excluded. The
participants who meet eligibility criteria completed computerized tasks of attentional
functioning in a second visit (Visit 2).
A subset of the children meeting criteria for the ASD/ADHD group (N=24) participated in a
six-week randomized double-blind, placebo-controlled treatment trial using various doses
(low, medium, or high dose) of methylphenidate (MPH). Children participated in the treatment
trial will be those who qualified based on the initial phase and who do not have any
physical contraindications to MPH (e.g., history of MPH intolerance). In each week of the
treatment trial, the children took one of the three doses of MPH or a placebo. At the end of
each week the child were evaluated in the clinic by including a medical check-up, parent
interviews about the child's behavior and functioning that week, and computerized cognitive
testing. Additionally, the child's parent and teacher completed questionnaires about the
child's behavior each week, so that the child's home and school behaviors at each MPH dose
could be assessed.
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| Criteria: |
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Inclusion Criteria:
Autism/ADHD Group:
- DSM-IV diagnosis of autistic disorder, as per the Autism Diagnostic Interview-Revised
(ADI-R) and the Autism Diagnostic Observation Schedule (ADOS)
- Child manifests current symptoms of ADHD
Autism/non-ADHD Group:
- Meets the diagnostic criteria for autism, as above, but does not meet the diagnostic
criteria for ADHD
Exclusion Criteria:
In both groups, exclusion criteria will include:
- Sensory or motor deficits sufficient to interfere with testing (e.g., blindness,
severe cerebral palsy)
- Serious neurological disorders (e.g., epilepsy, stroke)
- Down syndrome, fragile X syndrome, Tourette syndrome, or fetal alcohol syndrome
- Bipolar disorder or a family history of bipolar disorder in a first-degree relative
- Other serious psychopathology that resulted in psychiatric hospitalization (e.g., for
psychotic episode). The investigators will screen for this using the Diagnostic
Interview for Children and Adolescents (DICA)-IV, and getting a complete
developmental/medical history
- Serious physical handicaps that would interfere with performance on laboratory tasks
- IQ less than 50 and greater than 130
- Verbal mental age (VMA) less than 36 months (to exclude participants unable to
understand simple task instructions)
In the autism/ADHD group, further exclusion criteria apply to the MPH trial:
- History of intolerance to MPH
- Weight less than 20 kg or greater than 59 kg (less than 44 pounds or greater than 130
pounds)
- Concomitant use of dextroamphetamine preparations (Dexedrine, Dextrostat), mixed
amphetamine salts (Adderall XR), other MPH preparations (e.g., Concerta, Metadate);
venlafaxine, bupropion, atomoxetine, guanfacine, modafinil.
- Concomitant use of any herbal preparations
- Medical condition for which stimulants are contraindicated (e.g., high blood
pressure)
- Past treatment failure on a methylphenidate trial
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| NCT ID: |
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NCT00178503 |
| Primary Contact: |
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Principal Investigator
Deborah A. Pearson, PhD
The University of Texas Health Science Center, Houston
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| Backup Contact: |
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N/A |
| Location Contact: |
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Houston, Texas 77054
United States
There is no listed contact information for this specific location.
Site Status: N/A |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 24, 2013 |
| Modifications to this listing: |
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