View Clinical Trial (Medical Research Study)
Study Of PHarmacogenetics in Ethnically Diverse Populations (SOPHIE Study)
| City: |
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San Francisco |
| State: |
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California |
| Zip Code: |
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94143 |
| Conditions: |
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Focus Groups |
| Purpose: |
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Collect DNA from well-characterized healthy volunteers.
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| Study Summary: |
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DNA and plasma will be used to identify and determine allele frequencies of genetic variants
in membrane transporters and other genes relevant to human disease or drug response,
including drug metabolizing enzymes, collagen, race/ethnicity, neurovascular disease,
asthma/allergy/lung disease, and cardiovascular disease. This phase of the study will serve
as the hypothesis-generating phase for future studies by identifying genetic variants and
determining allele frequencies among an ethnically diverse cohort of healthy volunteers.
Future investigations (separate IRB applications) will attempt to correlate genotypes to
phenotypes among this cohort of volunteers. The allele identification and frequency data
from this group of healthy volunteers will also be used to design association studies in
relevant disease populations.
Determine if identified sequence variants are associated with gain or loss of in vitro
biologic function using lymphocytes obtained from patients.
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| Criteria: |
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Inclusion Criteria:
- Healthy adult subjects of both genders and all ethnic groups
- Subjects must be between 8-40 years of age
Exclusion Criteria:
- Smokers
- Drink > 2 alcoholic beverages/day
- Take any chronic medication
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| NCT ID: |
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NCT00187668 |
| Primary Contact: |
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Principal Investigator
Kathleen M Giacomini, PhD
Univeristy of California, San Francisco
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| Backup Contact: |
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N/A |
| Location Contact: |
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San Francisco, California 94143
United States
Hector Vizoso, RN-BC, MSN
Phone: 415-206-3317
Email: hvizoso@sfghgcrc.ucsf.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 25, 2013 |
| Modifications to this listing: |
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