View Clinical Trial (Medical Research Study)
Quetiapine for the Treatment of Insomnia Associated With Alzheimer's Disease
| City: |
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Burlington |
| State: |
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Vermont |
| Zip Code: |
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05401 |
| Conditions: |
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Alzheimer's Disease - Insomnia |
| Purpose: |
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The primary hypothesis is that quetiapine will improve sleep in persons with Alzheimer's
Disease (AD), with higher doses producing greater total sleep time and sleep efficiency.
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| Study Summary: |
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Quetiapine is frequently used to treat psychosis in patients with Alzheimer's disease (AD)
and other dementias. These patients commonly have sleep disturbances that include nighttime
awakenings with confused, agitated behaviors. These awakenings impose a great challenge for
caregivers, especially family caregivers whose own sleep is disrupted as a result of the
patient's awakenings. Sleep disturbance can lead to nursing home placement3 and may add to
cognitive impairment of patients.
There is no medication proven to be safe and effective in the treatment of sleep disorders
in patients with dementia. Antipsychotic medications are often prescribed at bedtime in the
hopes that they will aid sleep and reduce agitation and psychosis associated with these
awakenings. Sleep disturbance is more common in AD patients with moderate to severe disease,
and these patients are more likely to have psychosis and to be recruited from long-term care
facilities. We recently conducted the only multicenter clinical trial of a drug for sleep
disturbance in AD. The study, completed under the auspices of the NIA's Alzheimer's Disease
Cooperative Study, investigated melatonin as a sedative-hypnotic agent for AD patients. We
found melatonin to be of no benefit on objective measures, although there were positive
trends in the data and a significant improvement on subjective measures (caregiver ratings
of patients' sleep) in one of the melatonin groups relative to placebo. No other large trial
in AD subjects has been reported in the literature for drugs with potential benefit for AD
patients with sleep disturbances. There are several reasons why this population needs to be
specifically studied. Patients with AD tend to have highly fragmented sleep, with many
nocturnal awakenings. They have significant daytime sleepiness that might affect daytime
cognitive function and behavior. These patients tend to be older, with sensitivity to drug
side effects.
People with neurodegenerative diseases such as AD may respond differently to CNS-active
medications. Finally, this population represents a large and growing cohort of patients that
deserve individual study of their unique problems.
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| Criteria: |
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Inclusion Criteria:
1. Age 55-90 years.
2. Diagnosis of possible or probable AD as defined by NINCDS-ADRD criteria.
3. Sleep disturbance defined by mean score of 3 on first six items of the SDI.
4. Family member able to provide surrogate informed consent.
5. Live-in caregiver able to monitor medication and serve as informant on
questionnaires.
6. Caregiver who is fluent in English.
7. Be able to ingest oral tablets.
8. Be able to avoid caffeinated and alcoholic beverages during the study period.
9. A neuroimaging study at the time of initial diagnosis, or any time since that is
consistent with AD and effectively rules out dementia related only to stroke,
hydrocephalus or other neurological condition.
Exclusion Criteria:
1. Medical disorders that may account for sleep disturbance, especially delirium, Major
Depressive Disorder (DSMIV) and severe or significant acute or chronic pain.
2. Have acute or unstable medical conditions including renal failure, abnormal liver
function, cardiac arrhythmia, sitting blood pressure below 110/70 or above 140/100 or
postural blood drop 20 mm Hg.
3. Symptoms suggesting other sleep disorders (e.g., periodic limb movement disorder,
restless legs syndrome, obstructive sleep apnea syndrome), may be present but in the
opinion of the PI, do not account for the primary symptoms of insomnia.
4. Sleep disturbance symptoms that suggest a parasomnia. Parasomnias may include
behavioral manifestations of epileptiform activity or REM Behavior Disorder (RBD).
5. Previous treatment failure with quetiapine of AD-associated sleep disturbances, or
intolerance of quetiapine in a previous treatment trial.
6. Concomitant treatment with another antipsychotic or sedative-hypnotic medication,
including trazodone.
7. Evidence of a major mental disorder other than dementia, such as major depression or
schizophrenia.
8. Stable doses (for 4 weeks prior to study entry) of antidepressant, antiepileptic mood
stabilizer, or acetylcholinesterase inhibitor medication will be allowed, but
initiation or recent changes in the dose of such medications will be prohibited.
9. Benzodiazepines within 2 weeks of study entry will not be allowed.
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| NCT ID: |
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NCT00232570 |
| Primary Contact: |
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Principal Investigator
Clifford Singer, M.D.
University of Vermont
Sally Ross-Nolan, M.S.
Phone: 802-847-9488
Email: sally.nolan@vtmednet.org
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| Backup Contact: |
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Email: francine.nanda@vtmednet.org
Francine Nanda, M.S.
Phone: 802-847-8436
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| Location Contact: |
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Burlington, Vermont 05401
United States
Sally R. Nolan, M.S.
Phone: 802-847-9488
Email: sally.nolan@vtmednet.org
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 18, 2013 |
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