View Clinical Trial (Medical Research Study)
T Cell Repertoire Analysis of Immune Mediated Skin Diseases
| City: |
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Sacramento |
| State: |
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California |
| Zip Code: |
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95816 |
| Conditions: |
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Psoriasis - Mycosis Fungoides |
| Purpose: |
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This study is designed to identify the cells of the immune system that cause skin disease
such as psoriasis and mycosis fungoides. Blood samples from many patients will be compared
in hopes of finding common cells and molecules responsible for skin diseases. Results of
this study will increase our knowledge about immune mediated skin disease.
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| Study Summary: |
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The aim of the study is to characterized the T cell repertoire of individuals with immune
mediated skin disease (e.g. psoriasis and mycosis fungoides). Peripheral blood with be
collected from volunteers with psoriasis, mycosis fungoides and age matched controls.
Fifteen tablespoons of blood will be collected prior to the initiation of treatment and
again after the patient shows a clinical response to treatment. The time between blood
draws will be no less than 3 months. There will be no more than two blood draws per
patient. Blood samples will be used to determine the patient's HLA haplotype via PCR and
DNA sequencing. After the patient's haplotype has been established the activated T cell
repertoire will be analyzed for clonal expansions. Clonal expansions in the T cell
repertoire will be determined by immunoscope analysis, which is a PCR based technique.
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| Criteria: |
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Inclusion Criteria:
- Have an immune mediated skin disease, such as psoriasis or mycosis fungoides
- Are not taking immunosuppressive medications, which may interfere with T cell
analysis.
Exclusion Criteria:
- are taking immunosuppressive medications, which may interfere with T cell analysis
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| NCT ID: |
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NCT00368784 |
| Primary Contact: |
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Principal Investigator
Emanual Maverakis, MD
University of California, Davis
Emanaual Maverakis, MD
Phone: 916-734-1267
Email: emaverakis@ucdavis.edu
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| Backup Contact: |
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Email: jamie.chapman@ucdmc.udavis.edu
Jamie Chapman
Phone: 916-734-1267
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| Location Contact: |
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Sacramento, California 95816
United States
Emanual Maverakis, MD
Phone: 916-734-1267
Email: emaverakis@ucdavis.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 19, 2013 |
| Modifications to this listing: |
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