View Clinical Trial (Medical Research Study)
Growth of Airways and Lung Parenchyma
| City: |
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Indianapolis |
| State: |
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Indiana |
| Zip Code: |
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46202 |
| Conditions: |
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Infant, Premature - Bronchopulmonary Dysplasia - Asthma |
| Purpose: |
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The purpose of this study is to evaluate the growth of the lung and how easily gas can be
taken up by the lung in healthy infants born at full term without any breathing problems and
infants born prematurely.
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| Study Summary: |
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SPECIFIC AIM # 1: Determine the relationship between parenchymal tissue and alveolar volume
with normal lung growth early in life We hypothesize that during the first two years of life
that parenchymal surface area and alveolar volume increase with somatic growth; however, the
ratio of surface area to volume remains constant, while ventilation within the lung becomes
more homogenous.
SPECIFIC AIM # 2: Determine the pulmonary sequelae of premature birth and assess the
effectiveness of early treatment strategies upon the pulmonary sequelae.
We hypothesize that premature birth impedes growth and development of the lung parenchyma
and the airways at a corrected-age of 1-year. In addition, initiating continuous positive
airway pressure (CPAP) and a permissive ventilatory strategy in very premature infants at
birth will improve lung growth and lung function compared to treatment with early surfactant
and conventional ventilation.
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| Criteria: |
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Inclusion Criteria:
- Group 1
- full term greater than 37 weeks
- Group 3
- infants born premature between 23-35 weeks of age to be tested between the ages of
two to twenty four months corrected.
Exclusion Criteria:
- heart disease
- severe developmental delays
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| NCT ID: |
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NCT00419588 |
| Primary Contact: |
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Principal Investigator
Robert S. Tepper, MD, PhD
Indiana University
Christina Tiller, RRT
Phone: 317-944-3604
Email: ctiller@iupui.edu
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| Backup Contact: |
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N/A |
| Location Contact: |
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Indianapolis, Indiana 46202
United States
There is no listed contact information for this specific location.
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 24, 2013 |
| Modifications to this listing: |
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