View Clinical Trial (Medical Research Study)
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers
| City: |
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Bethesda |
| State: |
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Maryland |
| Zip Code: |
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20892 |
| Conditions: |
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Healthy |
| Purpose: |
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The Hematology Branch of the National Heart, Lung, and Blood Institute is doing a variety of
laboratory research experiments that require blood and tissue samples from healthy
volunteers. This protocol provides a mechanism for collecting these tissue samples. Research
includes studies of normal and abnormal formation of blood cells, viral blood diseases, the
role of the immune system in marrow failure and genetic risk factors for aplastic anemia.
Healthy normal volunteers 8 years of age and older may be eligible for this study. Samples
are collected as follows:
- Blood samples: Participants 8 years of age and older donate up to 4 tablespoons of
blood, which is obtained from a needle placed in an arm vein.
- Participants 8 years of age and older donate a buccal mucosa sample (cells from the
inside of the cheek). The inside of the cheek is scraped gently with a nylon brush.
- Participants 18 years of age and older donate a bone marrow sample. The bone marrow is
obtained from the hip bone. The skin over the area is wiped clean with alcohol and
iodine, and then a local anesthetic is injected under the skin and also into the bone.
When the area is numb, a bone marrow aspiration needle is introduced through the bone
surface into the marrow. The marrow cells are collected using a syringe connected to
the needle.
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| Study Summary: |
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The purpose of this protocol is to collect blood (ages 8 and older), bone marrow (ages 18
and older), skin tissue samples (ages 18 and older), and/or buccal mucosa samples (ages 8
and older) from healthy volunteers. Samples will be used for clinical and translational
research in the Hematology Branch and are indispensable for many of our research projects,
including studies of normal and abnormal hematopoiesis, the viral etiology of blood
diseases, the role of the immune system in marrow failure and genetic risk factors for
aplastic anemia. This protocol provides a mechanism for collection, tracking, storing,
dispensing, analyzing and disposing of these laboratory research samples.
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| Criteria: |
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- INCLUSION CRITERIA:
Self declared healthy volunteer.
Age 8 years and older (no upper limit) for blood and buccal mucosa sampling.
OR
Ages 18 years or older (no upper limit) for bone marrow or skin tissue sampling.
EXCLUSION CRITERIA:
Unable to comprehend the investigational nature of the protocol participation.
CBC determined outside expected normal ranges for the subject (bone marrow and skin tissue
donors only).
Pregnancy for skin tissue sampling, bone marrow aspirate and biopsy.
Age less than 18 years for skin tissue sampling, bone marrow aspirate and biopsy.
Off campus volunteers for skin tissue sampling bone marrow aspirate and biopsy.
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| NCT ID: |
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NCT00442195 |
| Primary Contact: |
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Principal Investigator
Neal S Young, M.D.
National Heart, Lung, and Blood Institute (NHLBI)
Kinneret S Broder
Phone: (301) 402-2837
Email: broderk@mail.nih.gov
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| Backup Contact: |
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Email: youngn@nhlbi.nih.gov
Neal S Young, M.D.
Phone: (301) 496-5093
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| Location Contact: |
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Bethesda, Maryland 20892
United States
For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)
Phone: 800-411-1222
Email: prpl@mail.cc.nih.gov
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 19, 2013 |
| Modifications to this listing: |
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