Treating Depression in African American Elders: A Community-Academic Partnership
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| City: |
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Philadelphia |
| State: |
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Pennsylvania |
| Zip Code: |
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19107 |
| Conditions: |
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Depression - Stress Reduction - Behavioral Activation Treatment |
| Purpose: |
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The specific primary aims of the study are to:
1. Test the immediate effect of the intervention at 4-months on depression in urban
African American older adults (primary trial outcome; between group comparison).
Hypothesis: Participants in the intervention group will report fewer depressive
symptoms in comparison to control group participants receiving usual care.
2. Test the maintenance effect of the intervention at 8-months on depression (within group
comparison). Hypothesis: Participants in the intervention group will maintain reduced
symptom presentation from 4 to 8 months.
3. Evaluate acceptability (social validity) of the intervention and extent of engagement
in activities by study participants (both intervention and wait-list control subjects).
A secondary aim of this study is to assess the feasibility of conducting a clinical trial
embedded in a community service setting and its dissemination using a community-academic
partnership. We also propose three exploratory aims. First, we seek to evaluate the
mechanisms of action, or pathways, by which treatment gains are obtained (Gitlin et al.,
2000). Given that behavioral activation represents conceptually the key active ingredient of
the proposed intervention, we plan to evaluate its mediational effect. Second, we seek to
evaluate whether the intervention has a differential treatment effect based on a study
participant's gender, age, and living arrangement (alone or with others). Given that
previous research suggests that participant characteristics may moderate depressive symptoms
and treatment outcomes, these exploratory analyses will provide insight as to whether this
particular treatment benefits some groups more than others. Third, we seek to evaluate
whether the intervention has short and long-term effects on quality of life, functional
difficulty, and self-efficacy to manage day-to-day tasks. Previous research has shown that
depressive symptoms exacerbate functional decline such that minimizing distress may have the
added value of enhancing function and perceived efficacy for this group over time.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
- African American
- ≥55 years of age
- English speaking
- Cognitively intact (MMSE >24)
- Depressed as measured by a score ≥5 on the PHQ-9
- Must have a telephone
- Planning to live in the area for 8 months
Exclusion Criteria:
- Not African American
- <55 years of age
- Does not speak English
- MMSE<24
- Not depressed as measures by a score of <5 on the PHQ-9
- Does not have a telephone
- Does not plan to live in the area for 8 months
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| NCT ID: |
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NCT00511680 |
| Primary Contact: |
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Principal Investigator
Laura N. Gitlin, Ph.D
Johns Hopkins University
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| Backup Contact: |
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N/A |
| Location Contact: |
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Philadelphia, Pennsylvania 19107
United States
There is no listed contact information for this specific location.
Site Status: N/A |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 20, 2013 |
| Modifications to this listing: |
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