View Clinical Trial (Medical Research Study)
A Case-Control Study of Prostate Cancer in the Greater Baltimore Area: An Epidemiological Study of Genetic Risk Factors for Prostate Cancer in African-American and Caucasian Males
| City: |
|
Baltimore |
| State: |
|
Maryland |
| Zip Code: |
|
21201 |
| Conditions: |
|
Prostate Cancer |
| Purpose: |
|
RATIONALE: Gathering information about genetic and environmental factors may help doctors
understand why African American men have an increased risk of prostate cancer and die more
often from prostate cancer than Caucasian men.
PURPOSE: This clinical trial is studying genetic and environmental risk factors in African
American and Caucasian healthy men and in patients with prostate cancer.
|
| Study Summary: |
|
OBJECTIVES:
Primary
- To identify genetic and environmental factors that predispose African-American males to
a higher prostate cancer incidence and mortality than Caucasians.
OUTLINE: This is a multicenter study.
All patients and healthy participants undergo collection of blood or mouth cells and urine.
Patients who undergo prostatectomy donate a sample of ther tumor for genotype, gene
expression, and protein expression analysis. Family cancer history, medical history, human
body, tobacco and alcohol use, medication, occupational history, lifestyle, sexual history,
diet, socioeconomic status, and additional risk factors are assessed using questionnaires
periodically.
|
| Criteria: |
|
DISEASE CHARACTERISTICS:
- Pathologically confirmed prostate cancer diagnosed within the past 2 years (patients)
- Identified through the Department of Motor Vehicle database (healthy participants)
- Matched by age (5-year intervals), gender, and race to patients (healthy
participants)
- Self-identified African-American and Caucasian males aged 40 to 90 years old who
reside in Baltimore City and surrounding areas including Western Maryland, Washington
DC, Virginia, West Virginia, Delaware, and Pennsylvania (patients and healthy
participants)
- Eligible for lung cancer case-control study (patients and healthy participants)
PATIENT CHARACTERISTICS:
- A non-objective statement to contact the patient must have been obtained from the
treating physician at the hospital where the patient was identified or from a
physician who is listed as the treating physician by the tumor registry or surgical
pathology report (patients)
- Never been interviewed as a control for the study (patients)
- Never been interviewed as a control for the study (with the study protocol tracking
database) (healthy participants)
- Must have a residential working phone within the home (patients and healthy
participants)
- Must have been born in the United States (patients and healthy participants)
- Must speak English well enough to be interviewed (patients and healthy participants)
- Physically and mentally capable of performing the interview (patients and healthy
participants)
- No severely ill patients in the intensive care unit (may be reconsidered as eligible
after discharge from intensive care unit) (patients)
- No diagnosis of HIV, hepatitis B, or hepatitis C (patients)
- No personal history of cancer other than basal cell or nonmelanoma skin cancer
(healthy participants)
- Not currently residing in an institution such as a prison, nursing home, or shelter
(patients and healthy participants)
- Able to give informed consent (patients and healthy participants)
PRIOR CONCURRENT THERAPY:
- No prior radiation therapy or chemotherapy (healthy participants)
|
| NCT ID: |
|
NCT00556725 |
| Primary Contact: |
|
Principal Investigator
Stefan Ambs, PhD
National Cancer Institute (NCI)
|
| Backup Contact: |
|
N/A |
| Location Contact: |
|
Baltimore, Maryland 21201
United States
Dean L. Mann, MD
Phone: 410-328-5512
Site Status: Recruiting |
| Data Source: |
|
ClinicalTrials.gov |
| Date Processed: |
|
June 18, 2013 |
| Modifications to this listing: |
|
Only selected fields are shown, please use the link
below to view all information about this clinical trial. |
|
Click to view Full Listing
|