View Clinical Trial (Medical Research Study)
SCCOR in Host Factors in Chronic Lung Diseases: Mechanisms of Immune Tolerance and Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA) in Patients With Cystic Fibrosis
| City: |
|
Pittsburgh |
| State: |
|
Pennsylvania |
| Zip Code: |
|
15213 |
| Conditions: |
|
Cystic Fibrosis - Allergic Bronchopulmonary Aspergillosis |
| Purpose: |
|
The goal of this study is to identify the immunological factors that influence a patient's
response to the presence of the fungus Aspergillus fumigatus (A. fumigatus) in the lungs. In
patients with cystic fibrosis (CF), this fungus is not known to cause damage to the lungs,
but some patients respond with an allergic reaction that cause them to wheeze, cough, or
have difficulty breathing. Approximately 230 patients will be enrolled with an additional 60
people who do not have CF and who do not have a history of asthma to serve as a comparison
group.
|
| Study Summary: |
|
|
| Criteria: |
|
Inclusion Criteria:
(CF)
- diagnosis of CF
- age 6 years or older
- presence of A. fumigatus in culture of airway flora, or the presence of one or more
of the diagnostic criteria for ABPA (Control)
- age and sex matched to CF population
Exclusion Criteria:
(CF)
- uncontrolled CF-related diabetes mellitus
- use of oral steroids at a dose ≥ 0.5 mg/kg/day
- history of lung transplantation
- pulmonary exacerbation as defined by requirement for use of intravenous antibiotics
or need for hospitalization within the preceding 14 days.
- patients who have a diagnosis of HIV and have a CD4+ Tcell count below 500 cells/ml
will be excluded (control)
- asthma
|
| NCT ID: |
|
NCT00585364 |
| Primary Contact: |
|
Principal Investigator
Jay K Kolls, MD
University of Pittsburgh
Elizabeth R Hartigan, MPH, RN
Phone: 412-692-7060
Email: elizabeth.hartigan@chp.edu
|
| Backup Contact: |
|
Email: adrienne.horn@chp.edu
Adrienne Horn, BSN, RN
Phone: 412-692-8069
|
| Location Contact: |
|
Pittsburgh, Pennsylvania 15213
United States
Elizabeth R Hartigan, MPH, RN
Phone: 412-692-7060
Email: elizabeth.hartigan@chp.edu
Site Status: Recruiting |
| Data Source: |
|
ClinicalTrials.gov |
| Date Processed: |
|
May 18, 2013 |
| Modifications to this listing: |
|
Only selected fields are shown, please use the link
below to view all information about this clinical trial. |
|
Click to view Full Listing
|