View Clinical Trial (Medical Research Study)
Contribution of Gabaergic and Glutamatergic Mechanisms to Cognitive Dysfunction
| City: |
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West Haven |
| State: |
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Connecticut |
| Zip Code: |
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06516 |
| Conditions: |
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Cognitive Dysfunction |
| Purpose: |
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This study investigates the interactions between NMDA (N-Methyl-D-aspartic acid) antagonism
and GABA (gamma-aminobutyric acid) system as it relates to cognitive function assessed by
ERPs (event-related potentials) in healthy volunteers.
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| Study Summary: |
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| Criteria: |
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Inclusion criteria:
- Ages of 21-45 years from all ethnic backgrounds.
- Male or female.
- Written informed consent.
Exclusion criteria:
- DSM-IV diagnosis for a psychotic, depressive or anxiety disorder.
- A history of significant medical/neurological disease such as cardiac, thyroid,
renal, hepatic abnormality, seizure disorder. Unstable medical condition based on
EKG, vital signs, physical examination and laboratory work-up (CBC with differential,
SMA-7, LFTs, TFTs, UA, Utox).
- History of abnormal EEG.
- History of severe allergies or multiple adverse drug reactions.
- Any medication that could interfere with either the safety of the study and/or the
outcome measures.
- Any other conditions which in the opinion of the investigator would preclude
participation in the study.
- History of major psychiatric disorder in first degree relatives.
- Current substance abuse/dependency determined by urine toxicology.
- Treatment with medications with CNS effects.
- Treatment with benzodiazepines within one week prior to testing.
- Current treatment with medications with psychotropic effects.
- Education < 10th grade.
- IQ < 70, MR.
- Non-English speaking.
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| NCT ID: |
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NCT00611572 |
| Primary Contact: |
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Principal Investigator
Handan Gunduz-Bruce, M.D.
Yale School of Medicine, Assistant Professor
Suravi Sircar, BS
Phone: 203 932 5711 ext. 5326
Email: suravi.sircar@yale.edu
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| Backup Contact: |
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N/A |
| Location Contact: |
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West Haven, Connecticut 06516
United States
Suravi Sircar, BS
Phone: 203-932-5711
Email: suravi.sircar@yale.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 22, 2013 |
| Modifications to this listing: |
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