View Clinical Trial (Medical Research Study)
Spreading Depressions as Secondary Insults After Traumatic Injury to the Human Brain
| City: |
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Richmond |
| State: |
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Virginia |
| Zip Code: |
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23298 |
| Conditions: |
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Traumatic Brain Injury |
| Purpose: |
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Since the primary damage from traumatic brain injury (TBI) is irreversible, the focus of
medical management of TBI is preventing secondary injury that can be life-threatening and
worsen patient outcome. Insight into the pathologic mechanisms of secondary injury, which
are largely unknown, is required for developing better treatments.
In preliminary studies, the investigators have found that a pathologic brain activity, known
as spreading depression, recurs in a large number of TBI patients in the first week after
injury. Spreading depressions are short-circuits of brain function that arise spontaneously
from an injury and spread repeatedly as waves into neighboring brain tissue. Animal
research has shown that spreading depressions can cause secondary injury to the brain.
The primary objective of this observational study is to determine whether the occurrence or
severity of spreading depression is related to worse neurologic recovery from TBI. Results
from the study will determine whether monitoring of spreading depression should be used as a
guide or target for improved medical management of the TBI patient.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
- 18-80 years old
- diagnosis of TBI
- craniotomy performed as per required treatment of TBI
- craniotomy surgery < 7 days after TBI
- GCS<13 at time of decision for surgery
- expected neuromonitoring for >72 hr
Exclusion Criteria:
- any failure to meet above criteria
- pregnancy
- GCS 3 with fixed, dilated pupils
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| NCT ID: |
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NCT00803036 |
| Primary Contact: |
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Principal Investigator
Jed A. Hartings, PhD
University of Cincinnati
Jed A. Hartings, PhD
Phone: 513-558-3567
Email: jed.hartings@uc.edu
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| Backup Contact: |
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N/A |
| Location Contact: |
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Richmond, Virginia 23298
United States
Bruce Mathern, MD
Phone: 804-828-9165
Email: bmathern@mcvh-vcu.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 25, 2013 |
| Modifications to this listing: |
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