View Clinical Trial (Medical Research Study)
The Expression and Significance of miRNA Profile and Markers of Inflammation in Patients With Pulmonary Arterial Hypertension
| City: |
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Columbus |
| State: |
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Ohio |
| Zip Code: |
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43210 |
| Conditions: |
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Pulmonary Arterial Hypertension |
| Purpose: |
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It is not always known what causes PAH or what the best treatment is. The doctors doing
this study would like to understand more about why some people develop PAH and other do not.
They also would like to learn more about which treatments might help PAH and which people
might respond better to treatments.
Doctors think that testing certain substances found in blood cells might help answer these
questions. These substances are normally released by our bodies to protect us from
infection and to tell the difference between normal and foreign substances in our body.
Finally, a new test will study very small molecules called microRNA that control how our
genes are expressed. This study is being done to see if blood samples can be tested to
determine who might develop PAH, how well drugs will work to treat PAH and to learn more
about the development of PAH.
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| Study Summary: |
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You will be asked to donate blood when you have your right heart catheterization and also at
the 3-4 month follow-up visit. The amount of blood collected during your heart
catheterization is about 20cc (about 4 teaspoons). This blood is discarded as part of the
clinical catheterization procedure, but we are asking that we use it for this research
study. Then, at the follow-up right heart catheterization, you will be asked to donate 20
cc (which is about 4 teaspoons) of blood.
If the second right heart is not required for clinical purposes then you will be asked to
give a blood sample during your 3-4 month follow up clinic visit.
If you require an additional right heart catheterization, within one year, we will ask that
you donate additional samples at the subsequent RHC.
Other data collected as part of your clinical care, such as medical history, chest x-ray
(picture of your lungs), echocardiogram (picture of your heart), ventilation perfusion scan
(determines how much blood goes to your lungs), chest CT (thin pictures of my lungs as
slices), pulmonary function tests (breathing tests), and lab blood tests, will be used as
part of this research.
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| Criteria: |
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Inclusion Criteria:
- ≥ 18 years of age
- Not pregnant
- Undergoing right heart catheterization for PAH diagnosis
Exclusion Criteria:
- Pregnant
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| NCT ID: |
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NCT00806312 |
| Primary Contact: |
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Principal Investigator
Namita Sood, MD
Ohio State University
Janice E. Drake, CRRT
Phone: 614-366-2287
Email: janice.drake@osumc.edu
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| Backup Contact: |
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Email: sharong.cheung@osumc.edu
Sharon Cheung, BS
Phone: 614-366-2258
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| Location Contact: |
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Columbus, Ohio 43210
United States
There is no listed contact information for this specific location.
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 19, 2013 |
| Modifications to this listing: |
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