View Clinical Trial (Medical Research Study)
Escitalopram for the Treatment of Postpartum Depression
| City: |
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Boston |
| State: |
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Massachusetts |
| Zip Code: |
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02114 |
| Conditions: |
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Postpartum Depression |
| Purpose: |
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The purpose of this study is to determine whether women with postpartum MDD will experience
a significant decrease in depressive symptoms from baseline over an eight-week treatment
intervention with escitalopram (Lexapro). Also, to determine whether women with postpartum
MDD will experience a significant decrease in anxiety symptoms.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
- Women ages 18 to 45 years old
- Subjects must meet criteria for a major depressive episode with symptoms developing
within three month of live childbirth
- Subjects must present within six months of childbirth
- MADRS score >15
- BAI score >10
- Subjects will be able to be treated on an outpatient basis
- Subjects will be able to provide written informed consent
Exclusion Criteria:
- Subjects who have taken any psychotropic medication, including antidepressants and
anti-anxiety medication, within the past two weeks (with the exception of
non-benzodiazepine medications used for sleep, including trazodone, zolpidem,
eszopiclone, etc)
- Suicidal ideation with active plan or intent, as determined by the investigator
- Presence of psychotic symptoms or homicidal ideation
- History of mania or hypomania
- Pregnant or breastfeeding
- Presence of chronic depression or dysthymia, or chronic or treatment resistant
anxiety disorders, as determined by investigator
- Active alcohol/substance abuse currently or within the past year
- Abnormal TSH, severe anemia, or uncontrolled hypertension
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| NCT ID: |
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NCT00833469 |
| Primary Contact: |
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Principal Investigator
Marlene P Freeman, MD
Massachusetts General Hospital
Stephanie D Connors, BS
Phone: 617-724-6989
Email: sdconnors@partners.org
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| Backup Contact: |
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Email: skfowler@partners.org
Suzanna Fowler, BA
Phone: 617-726-2912
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| Location Contact: |
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Boston, Massachusetts 02114
United States
Marlene P Freeman, MD
Phone: 617-643-6403
Email: mfreeman@partners.org
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 24, 2013 |
| Modifications to this listing: |
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