View Clinical Trial (Medical Research Study)
Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial
| City: |
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Pittsburgh |
| State: |
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Pennsylvania |
| Zip Code: |
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15213 |
| Conditions: |
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Bipolar Disorder - Major Depressive Disorder, Single Episode, Unspecified |
| Purpose: |
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The purpose of this study is to understand the efficacy of light therapy for bipolar
depression.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
- Ages 18-65 years
- DSM-IV Criteria BD I or II depressive episode,
- SIGH-ADS >20; duration >2 weeks.
- Stable dose antidepressant drug >8 weeks with concurrent antimanic drug
- Controlled thyroid disease
- Subjects with preexisting eye diseases will be included.
- Able to provide informed consent
- Stable minimum dose antimanic drug >4weeks: lithium 0.5 mEq/L, divalproex Na 50
mcg/mL, olanzapine 5mg daily, carbamazepine 4mg/L; lamotrigine 100mg daily,
risperidone 2mg daily, quetiapine 400 mg daily, ziprasidone 10 mg bid, and
aripiprazole 5 mg qd.
- Stable unchanged psychotherapy for >16weeks
Exclusion Criteria:
- The following eye diseases: retinal disease, cataract surgery and lens removal,
macular degeneration,
- Taking photosensitizing drugs such as phenothiazines (chlorpromazine), antimalarial
drugs, melatonin and hypericum.
- Acute psychosis (DSM-IV Criteria)
- Rapid cycling in the past 1 year
- Obsessive compulsive disorder
- Alcohol or substance abuse or dependence in the past 6 months.
- MRS>5
- Recent history of a suicide attempt (3 months) or active suicidal Ideation (SIGHADS
item H11 >2)
- Beta-adrenergic blockers, exogenous melatonin, chronic NSAIDS
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| NCT ID: |
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NCT00852592 |
| Primary Contact: |
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Principal Investigator
Dorothy K Sit, M.D.
University of Pittsburgh
Dorothy Sit, M.D.
Phone: 412-246-5248
Email: sitdk@upmc.edu
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| Backup Contact: |
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N/A |
| Location Contact: |
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Pittsburgh, Pennsylvania 15213
United States
Dorothy Sit, M.D.
Phone: 800-436-2461
Email: sitdk@upmc.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 20, 2013 |
| Modifications to this listing: |
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