Pharmacotoxicology of Trichloroethylene Metabolites
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| City: |
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Gainesville |
| State: |
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Florida |
| Zip Code: |
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32610 |
| Conditions: |
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Healthy |
| Purpose: |
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To establish the relationship between human MAAI haplotype and DCA and tyrosine metabolism.
This aim test the postulates that MAAI haplotype determines, and thus can predict,1)
dose-dependent DCA kinetics and biotransformation and 2) DCA's effects on tyrosine
metabolism.
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| Study Summary: |
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The arms of the study involves an admission to the clinical research center. There
participants will first take a low dose of DCA 2.5ug/kg for 5 days then wait 30 days and
take a therapeutic dose of DCA 25mg/kg for 5 days On the first day and on the 5th day of
taking DCA kinetics will be done. A total of 16 blood samples will be obtained through an
intravenous catheter. Subjects will also breath into a test tube for the collection of CO2.
Urine collection will also occur
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| Criteria: |
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Inclusion Criteria:
- Healthy volunteers
Exclusion Criteria:
- Pregnancy
- Other medications
- Psychiatric illness on meds
- Abnormal labs
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| NCT ID: |
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NCT00874276 |
| Primary Contact: |
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Principal Investigator
Peter W Stacpoole, PhD, MD
University of Florida
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| Backup Contact: |
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N/A |
| Location Contact: |
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Gainesville, Florida 32610
United States
There is no listed contact information for this specific location.
Site Status: N/A |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 18, 2013 |
| Modifications to this listing: |
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