View Clinical Trial (Medical Research Study)
Pharmacotoxicology of Trichloroethylene Metabolites: Kinetic Study of DCA in Persons Homozygous for KRT vs Wildtype
| City: |
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Gainesville |
| State: |
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Florida |
| Zip Code: |
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32610 |
| Conditions: |
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Healthy Volunteers |
| Purpose: |
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Specific Aim 2: Establish the relationship between human MAAI haplotype and DCA and
tyrosine metabolism. This aim tests the postulates that MAAI haplotype determines 1)
dose-dependent DCA kinetics and biotransformation and 2) DCA's effects on tyrosine
metabolism. Population pharmacogenetic analysis of MAAI allelic frequencies and GC or
LC-MS/MS techniques for blood or urinary metabolites will be used in these investigations.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
- Must be between 21 and 50 years of age
- Healthy subjects
- Males and females
Exclusion Criteria:
- Abnormal EKG
- Pregnancy
- Abnormal screening labs
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| NCT ID: |
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NCT00874705 |
| Primary Contact: |
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Principal Investigator
Peter W Stacpoole, PhD, MD
University of Florida
Peter W Stacpoole, PhD, MD
Phone: (352) 273-8700
Email: pws@ufl.edu
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| Backup Contact: |
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Email: bonnie.coats@medicine.ufl.edu
Bonnie S Coats, ARNP
Phone: (352) 392-6196
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| Location Contact: |
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Gainesville, Florida 32610
United States
There is no listed contact information for this specific location.
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 19, 2013 |
| Modifications to this listing: |
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