View Clinical Trial (Medical Research Study)
Oral Care Intervention in Mechanically Ventilated Adults
| City: |
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Richmond |
| State: |
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Virginia |
| Zip Code: |
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23298 |
| Conditions: |
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Nosocomial (Hospital-Acquired) Infections - Ventilator-Associated Pneumonia - Mechanical Ventilation - Endotracheal Intubation |
| Purpose: |
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Ventilator-associated pneumonia is a serious complication in mechanically ventilated
critically ill patients. The intervention tested in this project (swabbing the mouth with
chlorhexidine before the endotracheal tube is inserted) could reduce the risk of
ventilator-associated pneumonia.
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| Study Summary: |
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Ventilator-associated pneumonia (VAP) is an acute care complication with high morbidity and
mortality, which is costly in length of stay and resources used. Application of
chlorhexidine (CHX) to the mouths of critically ill adults after intubation reduces risk of
VAP. During intubation, organisms may be dragged by the tube from the contaminated mouth to
the sterile lung, and the endotracheal tube (ET) provides a pathway for direct entry of
bacteria from the mouth to the lower respiratory tract. However, procedures to decontaminate
the mouth before intubation are not routine and little is known about the effects of
pre-intubation CHX in critically ill patients. Thus, this project focuses on evaluating the
benefit of adding a pre-intubation CHX dose to the known benefit of post-intubation CHX to
reduce the risk of VAP. In order to examine the effect of pre-intubation CHX on early ET
colonization, we will perform microbial cultures of ETs of subjects who are extubated in the
first 24 hours of study participation. We will also explore selected biomarkers
(procalcitonin, cytokines) as indicators of development of VAP in a subset of subjects. The
project will add to knowledge about the relationships among oral health, ET intubation and
VAP, and addresses an important clinical outcome. Pre-intubation oral decontamination could
reduce risk of VAP and its associated morbidity and mortality.
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| Criteria: |
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Inclusion Criteria:
- Need for intubation
Exclusion Criteria:
- Pneumonia at the time of intubation
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| NCT ID: |
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NCT00893763 |
| Primary Contact: |
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Principal Investigator
Cindy L Munro, RN,ANP,PHD
Virginia Commonwealth University
Cindy L Munro, RN, ANP, PHD
Phone: 804-828-3410
Email: cmunro@vcu.edu
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| Backup Contact: |
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N/A |
| Location Contact: |
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Richmond, Virginia 23298
United States
There is no listed contact information for this specific location.
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 19, 2013 |
| Modifications to this listing: |
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