SCCOR in Host Factors in Chronic Lung Disease
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| City: |
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Chapel Hill |
| State: |
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North Carolina |
| Zip Code: |
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27599 |
| Conditions: |
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Chronic Obstructive Pulmonary Disease - Chronic Bronchitis |
| Purpose: |
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The purpose of this research is to understand the properties of mucus in persons with COPD,
specifically Chronic Bronchitis. We hypothesize that those with Chronic Bronchitis have
dehydrated mucus, and thus have a harder time coughing it out of their lungs. This leads to
a greater vulnerability for lung infection, inflammation and airflow obstruction.
Ultimately, our goal is to understand how mucus dehydration contributes to the progression
of COPD/Chronic Bronchitis so that better therapies and interventions can be developed for
future generations.
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| Study Summary: |
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Specific Aim I directly tests the hypothesis that mucus clearance is impaired due to mucus
dehydration. It measures 1) COPD Mucociliary and Cough Clearance 2) mucus hydration 3) the
concentrations of the dominant regulators of airway hydration and 4) the consequences of
mucus dehydration on mucus biophysical properties and bacterial infection.
Specific Aim II tests the hypothesis that COPD acute exacerbations are associated with
failures of mucus clearance. Measurements will be similar to that of Specific Aim I, but
conducted during periods of baseline health, acute exacerbation and recovery.
Specific Aim III tests whether airway surface hydration with 7% Hypertonic Saline will
restore clearance in the basal state and during a COPD acute exacerbation. COPD subjects
will be exposed to inhaled Hypertonic Saline during periods of baseline health and acute
exacerbation. Acute efficacy via measures of mucus clearance and spirometry will studied.
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| Criteria: |
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Inclusion Criteria:
- history of COPD/chronic bronchitis defined as having a productive cough for three
months of the year for at least two successive years
- greater than or equal to a 10 pack year cigarette smoking history
- ability to perform spirometry
Exclusion Criteria:
- unstable lung disease
- allergy to study medications
- radiation exposure within past year exceeding Federal Regulation Limits
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| NCT ID: |
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NCT00903955 |
| Primary Contact: |
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Principal Investigator
Richard Boucher, MD
University of North Carolina, Chapel Hill
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| Backup Contact: |
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N/A |
| Location Contact: |
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Chapel Hill, North Carolina 27599
United States
There is no listed contact information for this specific location.
Site Status: N/A |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 23, 2013 |
| Modifications to this listing: |
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