View Clinical Trial (Medical Research Study)
Neural Mechanism of the Effect of Acupuncture on Myocardial Ischemia
| City: |
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Irvine |
| State: |
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California |
| Zip Code: |
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92697 |
| Conditions: |
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Hypertension - Arrhythmias |
| Purpose: |
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Based on previous published research in animals, the investigators hypothesize that
electroacupuncture (EA) will have a positive effect on hypertension.
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| Study Summary: |
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The purpose of this study is to prove: (1) Myocardial ischemia, cardiac arrhythmias and
hypertensive response at rest and provoked by stress are decreased by EA; (2) The mechanism
of the ischemic response is an imbalance between myocardial oxygen supply and demand
originating as an increase in autonomic nervous system sympathetic activity causing
increased oxygen demand. EA inhibits the sympathetic nervous system, decreases blood
pressure and reduces the oxygen demand. Our prior data in animals shows that improvements
in cardiovascular function during myocardial ischemia are mediated by an EA-induced sensory
neural reflex originating in somatic nerves to reduce sympathetic nerve activity. The
specific aims of the present study will allow us to better understand and modulate the
sympathetic nervous discharge activity that can precipitate coronary ischemia, arrhythmias
and hypertension in exercise stress in humans. Potential clinical application is the
therapeutic value of EA in patients with hypertension.
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| Criteria: |
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Inclusion Criteria:
- Patients with mild coronary disease, and no significant ECG change reflecting
ischemia at rest
Exclusion Criteria:
- Pregnant or nursing women
- Individuals with severe coronary disease (continuous angina)
- Conduction abnormalities on ECG consistent with left bundle branch block
- Cardiac arrhythmias associated with low blood pressure (90 mmHg)
- Peripheral vascular disease
- Orthopedic disease
- Diabetic or psychological illness that could interfere with safe performance of
exercise of psychophysiological stress testing
- Those with known sensitivity to topical preparations or strong reactions to medical
dressings and skin tapes
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| NCT ID: |
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NCT00932139 |
| Primary Contact: |
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Study Director
Peng Li, MD, LAc
University of California, Irvine
Peng Li, MD, LAc
Phone: 949-824-6123
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| Backup Contact: |
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Sivarama Prasad Vinjamury
Phone: 562-947-8755 ext. 7364
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| Location Contact: |
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Irvine, California 92697
United States
Peng Li, MD, LAc
Phone: 949-824-6123
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 25, 2013 |
| Modifications to this listing: |
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