View Clinical Trial (Medical Research Study)
Effect of Bariatric Surgery-induced Weight Loss on Glucose Homeostasis
| City: |
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Saint Louis |
| State: |
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Missouri |
| Zip Code: |
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63110 |
| Conditions: |
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Morbid Obesity |
| Purpose: |
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The investigators wish to study the effects of two forms of bariatric surgery, gastric
bypass and lap banding. The surgery is not part of the clinical trial. If your insurance
does not cover the procedure, then you are responsible for payment of the surgical process.
We are doing pre and post surgery testing to provide a better understanding of the effect of
bariatric surgery-induced weight loss on metabolic function.
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| Study Summary: |
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Bariatric surgery is the most effective weight loss therapy for obesity. Moreover, the
early improvement in insulin sensitivity and the resolution of type 2 diabetes after
Roux-en-Y gastric bypass (RYGB) surgery has led to the hypothesis that bypassing the upper
gastrointestinal (GI) tract has specific beneficial effects on glucose homeostasis beyond
weight loss alone. However, this hypothesis has never been adequately evaluated in human
subjects. Therefore, the primary goal of this proposal is to provide a better understanding
of the effect of bariatric surgery-induced weight loss on insulin action and pancreatic beta
cell function.
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| Criteria: |
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Inclusion Criteria:
- BMI ≥ 35 kg/m2
- on stable dose of medications for at least 4 weeks before the pre-surgery metabolic
studies
Exclusion Criteria:
- smokes > 7 cigarettes per day
- previous malabsorptive or restrictive intestinal surgery
- pregnant or breastfeeding
- recent history of neoplasia (< 5 years ago)
- have malabsorptive syndromes and inflammatory intestinal disease
- diabetes mellitus
- show signs of oral disease or xerostomia (i.e., dry mouth)
- history of chronic rhinitis
- on medication that might affect metabolism
- severe organ dysfunction
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| NCT ID: |
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NCT00981500 |
| Primary Contact: |
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Principal Investigator
Samuel Klein, MD
Washington University School of Medicine
Courtney Tiemann, R.D.
Phone: 314-362-8250
Email: ctiemann@dom.wustl.edu
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| Backup Contact: |
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N/A |
| Location Contact: |
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Saint Louis, Missouri 63110
United States
Courtney Tiemann, R.D.
Phone: 314-362-8250
Email: ctiemann@wustl.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 18, 2013 |
| Modifications to this listing: |
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