View Clinical Trial (Medical Research Study)
In Vivo Confocal Microscopy Tumor Atlas Study
| City: |
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Phoenix |
| State: |
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Arizona |
| Zip Code: |
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85013 |
| Conditions: |
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Brain Neoplasms |
| Purpose: |
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This study aims to create an atlas based on the preliminary experience of the first
feasibility study in neurosurgery. Hypothesis: That a confocal endomicroscope can be used
during neurosurgery to provide in vivo histology that enables documentation of neurological
pathology across a range of tumor ypes and grades, suitable for comparison with traditional
histopathology from site‐matched biopsies.
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| Study Summary: |
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Confocal endomicroscopy is a medical imaging modality that allows real‐time microscopy to be
performed on living tissue in vivo. The procedure involves a small endoscope which is placed
gently into contact with the tissue, providing significant in vivo magnification on a scale
similar to that obtained by the pathology laboratory microscope. It is already in clinical
use in the field of gastroenterological endoscopy, and investigational use in laparoscopy,
dermatology and gynecology. Further, in recent pilot studies endomicroscopy has also been
shown to be feasible in bronchoscopy, robot assisted prostatectomy and neurosurgery.The
study will use both endomicroscopy and biopsy to document the histological appearance of a
range of neurological tumour types and grades.
In subsequent analysis, the confocal image data and corresponding histology data and images
will be used to document reliably observable features in the confocal images that are
relevant to histopathology interpretation. Relevant images will be selected and discussed by
comparison to frozen or permanent section histology for compilation into an atlas
documenting comparison for the tumors seen in the study.
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| Criteria: |
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Inclusion Criteria:
- All patients with neurological pathology requiring surgery in which tumour resection
might be evaluated by using biopsy
Exclusion Criteria:
- History of allergy to fluorescein
- Patients on beta‐blockers or ACE inhibitors
- Pregnant women
- Inability to give informed consent
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| NCT ID: |
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NCT01012154 |
| Primary Contact: |
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Principal Investigator
Peter Nakaji, MD
Barrow Neurological Institute, St. Joseph's Hospital and Medical Center
Peter Nakaji, MD
Phone: 602-406-4808
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| Backup Contact: |
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N/A |
| Location Contact: |
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Phoenix, Arizona 85013
United States
There is no listed contact information for this specific location.
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 23, 2013 |
| Modifications to this listing: |
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