View Clinical Trial (Medical Research Study)
Characterization of Circulating Tumor Cells (CTCs) to Direct Pre-Operative and Systemic Therapy in Patients With Locally Advanced or Metastatic Stage IV Breast Cancer
| City: |
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Duarte |
| State: |
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California |
| Zip Code: |
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91010 |
| Conditions: |
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Locally Advanced Breast Cancer - Metastatic (Stage IV) Breast Cancer - Stage III-IV Breast Cancer or Inflammatory |
| Purpose: |
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The purpose of this study is to identify tumor cells in the bloodstream (Circulating Tumor
Cells, CTC's) from patient's with locally advanced or metastatic (stage IV) breast cancer.
Analyzing the tumor is helpful in guiding therapy; however, research has suggested that the
number of tumor cells found in the bloodstream (CTC's) signifies more aggressive behavior
and increased difficulty in eliminating the cancer. This research will help to develop
better ways to treat breast cancer which could be tailored to a patient and may be adjusted
to a patient's individual needs.
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| Study Summary: |
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Up to 60 mL of blood will be collected from each patient at up to 6 time points. Samples
will be delivered to the Bruce Laboratory (Palo Alto Research Center) for immunolabeling and
FAST scanning. The FAST scanning will utilize CK+, CD45-and DAPI+ labeling as well as cell
morphology confirmed by collaborating pathologists to select for CTC with the technology
allowing for assessment of up to four additional protein expressions on the surface of
CTC's. Additional samples at the proposed time points will be placed on ice and sent over
to the Wang Laboratory for the purpose of extracting RNA/microRNA and proteins from CTC's
for profiling and further analysis. Benefits are only to society, not the individual.
Knowledge obtained from applying the two technologies may help with better selection of
therapy, early detection of progression, possibly better diagnosis and development of
targeted therapeutic agents in the future.
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| Criteria: |
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Inclusion Criteria:
- Patients must be > 18 years old.
- Patients are being treated for breast cancer at City of Hope (COH).
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| NCT ID: |
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NCT01048918 |
| Primary Contact: |
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Principal Investigator
Georg Somlo, MD
City of Hope Medical Center
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| Backup Contact: |
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N/A |
| Location Contact: |
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Duarte, California 91010
United States
Norma Baker, RN
Phone: 800-826-4673
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 17, 2013 |
| Modifications to this listing: |
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