View Clinical Trial (Medical Research Study)
Detection of Donor-Derived DNA in Semen Samples Among Recipients of Allogeneic Hematopoietic Stem-Cell Transplants
| City: |
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Nashville |
| State: |
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Tennessee |
| Zip Code: |
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37232 |
| Conditions: |
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Cancer Survivor - Chronic Myeloproliferative Disorders - Leukemia - Lymphoma - Multiple Myeloma and Plasma Cell Neoplasm - Myelodysplastic Syndromes - Myelodysplastic/Myeloproliferative Neoplasms - Neuroblastoma - Testicular Germ Cell Tumor |
| Purpose: |
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RATIONALE: Studying samples of semen from cancer survivors in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This phase I research study is looking at the presence of donor-derived DNA in
semen samples form cancer survivors who underwent donor stem cell transplant.
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| Study Summary: |
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OBJECTIVES:
- To examine semen samples from male survivors of allogeneic hematopoietic stem cell
transplantation for the presence of donor-derived DNA.
OUTLINE: Semen samples are collected and assessed by flow cytometry and PCR. DNA samples are
compared to previously analyzed DNA extracted from survivor and donor. Samples are also
analyzed for sperm concentration, motility, morphology, and viability.
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| Criteria: |
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DISEASE CHARACTERISTICS:
- Disease in remission
- More than 365 days since prior allogeneic hematopoietic stem cell transplantation
with history of full donor engraftment
- Stable complete donor chimerism
PATIENT CHARACTERISTICS:
- Able to consent and willing to provide a semen sample
- Survivors who present for long-term follow-up appointments in the adult and pediatric
stem cell transplant clinic at Vanderbilt University Medical Center
- No known history of infertility or azospermia
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No history of testicular irradiation ≥ 200 cGy
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| NCT ID: |
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NCT01077440 |
| Primary Contact: |
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Principal Investigator
Haydar A. Frangoul, MD
Vanderbilt-Ingram Cancer Center
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| Backup Contact: |
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N/A |
| Location Contact: |
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Nashville, Tennessee 37232
United States
Clinical Trials Office - Vanderbilt-Ingram Cancer Center
Phone: 800-811-8480
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 24, 2013 |
| Modifications to this listing: |
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