| Conditions: |
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Pediatric Cancer - Leukemia - Sarcoma - Brain Tumors |
| Purpose: |
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Background:
- The Children's Oncology Group has established a research network, the Childhood Cancer
Research Network (CCRN), to collect information about children with cancer and other
conditions that are benign but involve abnormal cell growth in order to help doctors and
scientists better understand childhood cancer. The CCRN's goal is to collect clinical
information about every child diagnosed with cancer and similar conditions in the United
States and Canada, to allow researchers to study patterns, characteristics, and causes of
childhood cancer. The information can also help researchers study the causes of childhood
cancer. To expand the CCRN, parents of children who have been diagnosed with cancer will be
asked to provide information about themselves and their child for research purposes.
Objectives:
- To obtain informed consent from parents (and the child, when appropriate) of infants,
children, adolescents, and young adults newly diagnosed with cancer to enter their
names and certain information concerning their child into the Childhood Cancer Research
Network.
- To obtain informed consent from parents (and the child, when appropriate) of infants,
children, adolescents, and young adults newly diagnosed with cancer for permission to
be contacted in the future to consider participating in non-therapeutic and prevention
research studies involving the parents and/or the child.
Eligibility:
- Parents of children who have been seen at or treated by a hospital that is a member of the
Children's Oncology Group.
Design:
- Parents will provide permission to have personal information sent from their child's
hospital to the CCRN, including the child and parents' names; child's gender, birth
date, race, and ethnicity; information about the disease; and the treating institution.
- Parents will also give permission for CCRN to contact the diagnostic laboratory to
obtain specific information about the tumor or cancer cells.
- Parents will be asked if they are willing to be contacted in the future to consider
participating in CCRN research studies, and will provide contact information (name,
home address, and telephone number) to be entered in the CCRN.
- Parents or patients who change their minds about having information available in the
CCRN can ask the treatment institution to restrict access to the identifying
information. Parents or patients who refuse to have information included in the CCRN or
be contacted in the future will still be able to enter clinical cancer research
studies.
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| Study Summary: |
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Background:
- Institutional membership in the Children's Oncology Group (COG) requires registration
of all pediatric cancer patients seen at their site. This registration process includes
all patients.
- In order to maximize the resource that a network would provide, it is necessary to have
identifying information on a large proportion of the cases included within the network.
Moreover, the resource would be further enhanced if informed consent from
parents/patients was obtained to allow future contact regarding possible participation
in non-therapeutic and prevention research.
Objectives:
- To obtain informed consent from parents of infants, children, adolescents, and young
adults newly diagnosed with cancer (and their child when appropriate) to enter their
names and certain information concerning their child into the Childhood Cancer Research
Network and/or for permission to be contacted in the future to consider participating
in future studies.
- For children under the age of majority at the time of parental consent: Once the child
reaches the age of majority, to obtain informed consent from that child to allow
her/his name and other identifying information to continue to be available to the
Childhood Cancer Research Network and/or to be possibly contacted in the future to
consider participating in other studies.
Eligibility:
- Pre-CCRN Entry
- All new patients seen in COG member institutions with any of the following diagnoses
are eligible:
-- All cancer cases with an ICD-O histologic behavior code of two 2 (carcinoma in
situ)or three 3 (malignant).
- -All lesions of the central nervous system regardless of behavior, i.e., benign,
borderline or malignant.
- The benign/borderline conditions which will be reportable by agreement shall
include: Mesoblastic nephroma, all teratomas, regardless of locations, Theca cell
- granulosa cell tumor, lymphoproliferative disease, ganglioneuroma,
myeloproliferative disease, Langerhan's Cell histiocytosis
Design:
If consent to enter the patient in ACCRN07 is obtained:
1. Using the patient's COG ID, the CCRN consent will be added to their record and the
patient will be considered registered with COG.
2. Depending on the response on the consent form, the record will be flagged for a yes'
or no' to possible contact for future studies in the CCRN.
If consent is not obtained to enter the patient in ACCRN07
1. For those parents/patients who refuse the CCRN consent, they will still be able to be
enrolled on any COG clinical trial (therapeutic and non- therapeutic) for which the
patient is eligible. The unique COG ID will be used to identify the patient.
2. The information collected as part of the study entry procedures will not be available
to the CCRN. The record will be flagged as refusing participation in the CCRN.
3. If consent is later obtained for enrollment in the CCRN, the patient must be entered in
ACCRN07 using the patient's unique COG ID.
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| Criteria: |
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- INCLUSION CRITERIA:
- Pre-CCRN Entry
- All new patients seen in COG member institutions with any of the following diagnoses
are eligible:
- All cancer cases with an ICD-O histologic behavior code of two 2 (carcinoma in
situ)or three 3 (malignant).
- All lesions of the central nervous system regardless of behavior, i.e., benign,
borderline or malignant.
- The benign/borderline conditions which will be reportable by agreement shall
include: Mesoblastic nephroma, all teratomas, regardless of locations, Theca
cell
- granulosa cell tumor, lymphoproliferative disease, ganglioneuroma,
myeloproliferative disease, Langerhan's Cell histiocytosis
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| NCT ID: |
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NCT01117168 |
| Primary Contact: |
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Principal Investigator
Crystal L Mackall, M.D.
National Cancer Institute (NCI)
Sharon Mavroukakis, R.N.
Phone: (301) 496-4164
Email: mavroukakis@nih.gov
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| Backup Contact: |
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Email: mackallc@pbmac.nci.nih.gov
Crystal L Mackall, M.D.
Phone: (301) 402-5940
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| Location Contact: |
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Bethesda, Maryland 20892
United States
For more information at the NIH Clinical Center contact National Cancer Institute Referral Office
Phone: (888) NCI-1937
Site Status: Recruiting |