View Clinical Trial (Medical Research Study)
Role of Cysteinyl Leukotrienes in the Pathogenesis of Asthma in Obesity
| City: |
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Ann Arbor |
| State: |
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Michigan |
| Zip Code: |
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48109 |
| Conditions: |
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Asthma - Obesity |
| Purpose: |
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The purpose of this study is to examine whether there are higher levels of cysteinyl
leukotrienes in obese subjects than in non-obese subjects. Cysteinyl leukotrienes are
pro-inflammatory substances that cause asthma by narrowing the airways of the lung. The
investigators want to see if subjects with increased fat stores and therefore increased
leptin, which is a fat-related protein that regulates leukotrienes, have increased levels of
leukotrienes in the blood, lung and urine. The investigators would also like to determine
the relationship between cysteinyl leukotrienes and exhaled nitric oxide levels in
asthmatics with and without obesity. Nitric oxide is anti-inflammatory and suppresses
leukotriene synthesis.
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| Study Summary: |
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This is a cross-sectional observational study to characterize the association between obese
asthmatics and the inflammatory mediators cysteinyl leukotrienes. Our hypothesis is that
altered adipokine levels in obesity result in augmented cysteinyl leukotriene synthesis that
play a significant role in the pathogenesis of asthma in these subjects.
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| Criteria: |
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Inclusion Criteria:
- 18-65 yr old adults with asthma, non-smoking for at least one year
- Healthy non-smoking adults, aged 18-65 without asthma
- Heavy subjects with BMI > 30 kg/m2
- Subjects with normal weight (BMI between 20-25 kg/m2)
- Subject not taking anti-leukotriene therapy (Singulair, Accolate, Zyflo)
Exclusion Criteria:
- No chronic oral steroid use
- No recent history of infection
- No recent history of flare of lung disease
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| NCT ID: |
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NCT01158573 |
| Primary Contact: |
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Principal Investigator
Michael Coffey, MD
University of Michigan Health System
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| Backup Contact: |
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N/A |
| Location Contact: |
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Ann Arbor, Michigan 48109
United States
Barbara A Torretti, BA
Phone: 734-936-9875
Email: btorrett@med.umich.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 18, 2013 |
| Modifications to this listing: |
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