View Clinical Trial (Medical Research Study)
Cerebral Perfusion Pressure Using Precedex and Other Sedatives
| City: |
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Durham |
| State: |
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North Carolina |
| Zip Code: |
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27710 |
| Conditions: |
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Endotracheal Intubation - Continuous IV Sedation - ICP Monitoring |
| Purpose: |
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The purpose of this study is to examine the effects of using dexmedetomidine (Precedex) in
addition to the current standard-of-care for sedation.
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| Study Summary: |
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Primarily, this study seeks to explore whether there is a difference in mean arterial
pressure (MAP) variability, incidence of intracranial hypertension, intracranial pressure
(ICP) variability, cerebral perfusion pressure (CPP) and Cerebrovascular pressure reactivity
index (PRx) in two groups of subjects.
Patients must be submitted to the ICU and be endotracheally intubated and receiving
mechanical ventilation with continuous IV sedation for less than 24 hours after recruitment
into the study.
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| Criteria: |
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Inclusion Criteria:
- Admitted to Duke University NCCU
- Adult (18 years of age or older)
- Expected Mechanical Ventilation for >48 hours with sedation
- Intraventricular catheter in situ
Exclusion Criteria:
- Hypersensitivity to study drugs
- Prisoners
- Moribund state or death expected within 24 hours
- Surgery planned within 24 hours of subject enrollment
- Receiving study drug, Precedex, prior to entering study
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| NCT ID: |
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NCT01169467 |
| Primary Contact: |
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Principal Investigator
Keith Dombrowski, MD
Duke University
Keith Dombrowski, MD
Phone: (919) 684-8246
Email: keith.dombrowski@dm.duke.edu
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| Backup Contact: |
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Email: kristina.riemen@duke.edu
Kristina Riemen
Phone: (919) 684-0071
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| Location Contact: |
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Durham, North Carolina 27710
United States
Keith Dombrowski, MD
Phone: 919-684-8246
Email: keith.dombrowski@dm.duke.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 24, 2013 |
| Modifications to this listing: |
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