View Clinical Trial (Medical Research Study)
Genetic Epidemiology of Severe, Early-Onset Chronic Obstructive Pulmonary Disease
| City: |
|
Boston |
| State: |
|
Massachusetts |
| Zip Code: |
|
02115 |
| Conditions: |
|
Chronic Obstructive Pulmonary Disease |
| Purpose: |
|
Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but
genetic predisposition also influences COPD susceptibility. The purpose of this study is to
identify genetic factors that predispose some individuals to develop COPD.
|
| Study Summary: |
|
Chronic obstructive pulmonary disease (COPD), which is the third leading cause of death in
the United States, affects millions of people around the world. COPD, which can include
both emphysema and chronic bronchitis, affects the lungs making it very difficult to
breathe. Cigarette smoking is the most common risk factor for developing COPD; however,
only 15% to 20% of smokers develop COPD in their lifetimes. The onset of COPD also varies
greatly from person to person; while some people do not develop respiratory symptoms until
later in life, there are others who develop severe COPD at a very early age. Prior research
has led to the discovery of the alpha-1 antitrypsin protein deficiency in association with
COPD development. This discovery has generated further interest toward studying other
genetic factors which may also affect an individual's likelihood of developing COPD.
Therefore, the purpose of the Boston Early-Onset COPD study is to gain a better
understanding of COPD risk factors in order to establish new possible methods of treatment
for people affected by COPD.
For this study we are enrolling individuals affected with severe COPD (52 years old or
younger with an FEV1 < 40%) and their family members. Each participant will attend one
study visit that involves a respiratory questionnaire, a breathing test, and blood draw.
This visit can be completed at the participant's home, in the hospital, or by long distance
data collection (phone interview, local breathing tests, and local blood draw with mailed
samples), whichever is preferred.
|
| Criteria: |
|
Inclusion Criteria for Early-Onset COPD Probands:
- Early onset of COPD in individuals younger than 53 years old
- Spirometry results that are indicative of severe COPD (FEV1 < 40% predicted)
- Physician-diagnosed COPD
Exclusion Criteria for Early-Onset COPD Probands:
- Severe alpha-1 antitrypsin deficiency
- Other chronic lung diseases in participants with COPD (except asthma)
- Pregnant
- Any previous lung surgery including lung transplant or lung reduction volume surgery
(LVRS); unless prior Pulmonary Function Tests are available
|
| NCT ID: |
|
NCT01177618 |
| Primary Contact: |
|
Edwin K. Silverman, M.D., Ph.D.
Phone: 617-525-2128
Email: ed.silverman@channing.harvard.edu
|
| Backup Contact: |
|
N/A |
| Location Contact: |
|
Boston, Massachusetts 02115
United States
Leif Skjerli
Phone: 617-525-2075
Email: leif.skjerli@channing.harvard.edu
Site Status: Recruiting |
| Data Source: |
|
ClinicalTrials.gov |
| Date Processed: |
|
June 19, 2013 |
| Modifications to this listing: |
|
Only selected fields are shown, please use the link
below to view all information about this clinical trial. |
|
Click to view Full Listing
|