View Clinical Trial (Medical Research Study)
Impedance Cardiographic Assessment of Gravidas With Severe Hypertension (ICASH)to Assess Impact of Standard Therapy on Hemodynamic Parameters - A Pilot Study
| City: |
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Jackson |
| State: |
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Mississippi |
| Zip Code: |
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39216 |
| Conditions: |
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Pregnancy; Proteinuria, With Hypertension (Severe Pre-eclampsia) - Delivery; Proteinuria, With Gestational Hypertension (Pre-eclampsia, Severe) - Pregnancy; Hypertension, Gestational Hypertension, With Albuminuria (Severe Pre-eclampsia) |
| Purpose: |
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The utilization of external cardiohemodynamic patient assessment, applying non-invasive
stick-on contact patches to the mother's neck on either side and chest wall on either side,
enables the practitioner to have information about the patient's cardiac function and
vascular status beyond simply blood pressure and pulse. This information, once collected,
should open the practitioner's eyes to better assess the patient's disease status and her
response to therapy. We will use this information to compare the effectiveness of the two
standard medications used for treatment of maternal high blood pressure.
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| Study Summary: |
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Pregnant patients with severe acute hypertension due either to superimposed preeclampsia,
severe preeclampsia or severe gestational hypertension will be randomized to receive either
of two antihypertensive agents (hydralazine or labetalol). Just before drug administration
and immediately thereafter impedance cardiography of the patient will be undertaken and the
results analyzed relative to the cardiac profile and the drug administered to reduce the
severe hypertension.
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| Criteria: |
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Inclusion Criteria:
- Nulliparous or parous patients with severe hypertension
- Singleton gestation
- Gestational age greater than 20 weeks
Exclusion Criteria:
- Multiple gestation
- Gestational age less than 20 weeks
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| NCT ID: |
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NCT01248169 |
| Primary Contact: |
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Principal Investigator
James N Martin, MD
SOM-Obstetrics & Gynecology
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| Backup Contact: |
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N/A |
| Location Contact: |
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Jackson, Mississippi 39216
United States
Sheila K Belk
Email: sbelk@umc.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 18, 2013 |
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