View Clinical Trial (Medical Research Study)
Effect of Remote Ischemic Preconditioning in Children Undergoing Cardiac Surgery
| City: |
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Seattle |
| State: |
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Washington |
| Zip Code: |
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98105 |
| Conditions: |
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Congenital Heart Disease - Cardiopulmonary Bypass - Myocardial Injury - Acute Kidney Injury - Acute Lung Injury |
| Purpose: |
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Remote Ischemic Preconditioning (RIPC) is a treatment that may be associated with improved
outcomes after cardiac surgery. It can be elicited noninvasively by using a tourniquet to
elicit transient ischemia over a lower extremity. It is thought to promote
anti-inflammatory and cell survival pathways, and thus protect remote organs against future
ischemic injury. We hypothesize that compared to sham treatment, RIPC will be associated
with decreased post-operative acute kidney, myocardial, and lung injury.
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| Study Summary: |
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In children undergoing cardiac surgery and cardiopulmonary bypass (CPB), our primary aims
are to determine whether RPC is associated with: 1) decreased AKI and 2) decreased acute
myocardial injury. Secondary aims include investigating the effects of RPC on
post-procedure: 1)acute lung injury and 2) morbidity/mortality.
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| Criteria: |
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Inclusion Criteria:
Age birth to 18 years Cardiac surgery with planned cardiopulmonary bypass
Exclusion Criteria:
Any contraindication to compression of lower extremity/extremities Body weight <2 kg
Active infection going into surgery On renal replacement therapy (RRT) or mechanical
circulatory support going into surgery On inotropic support going into surgery
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| NCT ID: |
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NCT01260259 |
| Primary Contact: |
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Principal Investigator
Christine W Hsu, MD
Seattle Children's Hospital and University of Washington
Christine W Hsu, MD
Phone: 206-987-2524
Email: christine.hsu@seattlechildrens.org
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| Backup Contact: |
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Email: yuk.law@seattlechildrens.org
Yuk Law, MD
Phone: 206-987-5607
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| Location Contact: |
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Seattle, Washington 98105
United States
Christine W Hsu, MD, MS
Phone: 206-543-2346
Email: cwhsu8@uw.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 19, 2013 |
| Modifications to this listing: |
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