View Clinical Trial (Medical Research Study)
Imaging of Cognition, Learning, and Memory in Aging
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New York |
| State: |
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New York |
| Zip Code: |
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10032 |
| Conditions: |
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Alzheimer's Disease |
| Purpose: |
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This investigation is designed to study how the brain functions when it is performing
explicit memory tasks, and furthermore how the brain systems supporting performance on these
tests change as a function of aging. Implicit memory tasks may be distinguished from
explicit memory tests in that explicit memory characterizes the directed or intentional
recollection of previously learned information or events. In contrast, implicit (or
nonconscious) memory is expressed in the facilitation of performance on some task or
judgment on a stimulus owing to a prior presentation of that stimulus, without any necessary
conscious awareness of the prior presentation. The investigators propose to use functional
Magnetic resonance Imaging (fMRI) to measure brain activity during the performance of
carefully designed explicit memory tasks. Comparison of brain activity during the different
test conditions will provide information about the brain areas that are involved in
mediating specific aspects of performance. Both older and younger individuals will be tested
in order to understand age related changes in the brain activity. In order to examine the
interactions between participants' differential levels of amyloid burden and their
performance on cognitive tasks and fMRI neural activation, the investigators also propose
PET imaging of older participants.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
- Aged 18-30 or 65-85
- Residing in the community of Washington Heights/Inwood/Hamilton Heights
- Must be willing and able to participate
Exclusion Criteria:
- Have a contraindication to PET (e.g, metallic implants, pacemaker, claustrophobia, or
cannot lie flat for one hour)
- Pregnancy
- Lactating Women
- Current, past, or anticipated exposure to radiation
- Significant active physical illness
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| NCT ID: |
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NCT01297114 |
| Primary Contact: |
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Principal Investigator
Yaakov Stern, PhD
Columbia University
Daniel J Barulli, M.A.
Phone: 212-305-9712 ext. 5-9712
Email: djb2168@columbia.edu
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| Backup Contact: |
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Email: akp2112@columbia.edu
Amanda K Phingbodhipakkiya, B.S.
Phone: 212-342-4150 ext. 2-4150
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| Location Contact: |
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New York, New York 10032
United States
There is no listed contact information for this specific location.
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 17, 2013 |
| Modifications to this listing: |
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