View Clinical Trial (Medical Research Study)
Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora Populations
| City: |
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Bethesda |
| State: |
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Maryland |
| Zip Code: |
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20892 |
| Conditions: |
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Diabetes - Cardiovascular Disease |
| Purpose: |
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Background:
- African Americans have one of the highest rates of type 2 diabetes in the United States,
and often have other medical problems related to obesity and cardiovascular disease. These
conditions have various risk factors, including high blood sugar levels, high cholesterol
levels, and insulin resistance. However, these risk factors have not been studied very
closely in individuals with African ancestry, including Afro-Caribbean and sub-Saharan
Africa migrant populations. Researchers are interested in conducting a genetic study on
obesity, adult-onset diabetes, heart disease, and other common health conditions in
individuals with African ancestry.
Objectives:
- To collect genetic and non-genetic information from individuals with African ancestry to
study common health conditions related to obesity, adult-onset diabetes, and heart disease.
Eligibility:
- Individuals at least 18 years of age who self-identify as African American,
Afro-Caribbean, or migrants from sub Saharan Africa.
Design:
- Participants will undergo a physical examination and will provide a blood sample for
study.
- Participants will also answer questions about personal and family medical history and
current lifestyle behaviors.
- No treatment will be provided as part of this protocol.
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| Study Summary: |
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This research protocol is designed to study the genetic basis of the clustering of several
metabolic disorders including Type 2 diabetes (T2D), hypertension, cardiovascular diseases
(CVD), obesity, and other related conditions in populations of the African Diaspora. This
project takes advantage of the well-established infrastructure and success of Dr. Anne
Sumner's NIDDK clinical protocols. The project will aim to enroll subjects from her cohorts
which include whites, African Americans and Africans living in the United States with the
goal of performing quantitative trait analysis using a candidate gene approach to understand
the genetic basis of serum lipid levels, blood pressure, fasting glucose, and other
metabolic parameters. For aim 2, we propose to perform whole exome sequencing in a subset
of cases (n=48, 96 chromosomes) to identify both rare and common variants for multiple
metabolic parameters. Variants identified by the exome sequencing effort and by a current
sequencing project of six candidate lipid genes will be genotyped in the entire cohort.
Overall, these studies will further efforts to understand if black-white differences as well
as differences within black populations exist in the genetic basis of T2D, CVD, and obesity.
Given past activities, it is also anticipated that this resource will form the basis of
multiple collaborations between Dr. Rotimi's lab, several NIH intramural researchers, and
non-NIH scientists.
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| Criteria: |
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- INCLUSION CRITERIA:
Subjects will include unrelated persons who self-identify as white or African American,
Afro-Caribbean or migrant from sub-Saharan Africa. Adults of African ancestry are
prioritized for this study because of the paucity of genetics studies investigating the
association of risk alleles contributing to the prevalence of T2D, CVD, obesity and other
common conditions in this population.
EXCLUSION CRITERIA:
Children are excluded as these phenotypes present more commonly in adults. Attempts will
be made to enroll an equal number of men and women. No prisoners, pregnant women or
fetuses will be included in this study.
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| NCT ID: |
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NCT01316783 |
| Primary Contact: |
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Principal Investigator
Charles N Rotimi, M.D.
National Human Genome Research Institute (NHGRI)
Shirley Freeman
Phone: (301) 451-2302
Email: freemansh@mail.nih.gov
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| Backup Contact: |
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Email: rotimic@mail.nih.gov
Charles N Rotimi, M.D.
Phone: (301) 451-2303
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| Location Contact: |
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Bethesda, Maryland 20892
United States
For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)
Phone: 800-411-1222
Email: prpl@mail.cc.nih.gov
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 23, 2013 |
| Modifications to this listing: |
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