View Clinical Trial (Medical Research Study)
Exercise Versus Diet in the Treatment of Nonalcoholic Fatty Liver Disease
| City: |
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Columbia |
| State: |
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Missouri |
| Zip Code: |
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65212 |
| Conditions: |
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Non Alcoholic Fatty Liver Disease |
| Purpose: |
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The central hypothesis of this proposal is that a reduction in hepatic mitochondrial
function is the main pathophysiology behind NAFLD (Non-Alcoholic Fatty Liver Disease) and
NASH (Non alcoholic steatohepatitis). The investigators further hypothesize that lifestyle
modifications through aerobic exercise training without weight loss or diet-induced weight
loss are effective in reducing NAFLD parameters by improving hepatic mitochondrial content
and function in human subjects.
The investigators propose a randomized, controlled human clinical trial to compare the
effects of aerobic exercise training (without weight loss) versus diet-induced weight loss
(without exercise) in individuals who have NAFLD or liver biopsy-confirmed NASH
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| Study Summary: |
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Fatty Liver Disease) and NASH (Non alcoholic steatohepatitis). The investigators further
hypothesize that lifestyle modifications through aerobic exercise training without weight
loss or diet-induced weight loss are effective in reducing NAFLD parameters by improving
hepatic mitochondrial content and function in human subjects.
The investigators propose a randomized, controlled human clinical trial to compare the
effects of aerobic exercise training (without weight loss) versus diet-induced weight loss
(without exercise) in individuals who have NAFLD or liver biopsy-confirmed NASH
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| Criteria: |
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Inclusion Criteria:
- sedentary individual between
- age group 18-60 years old
- elevated Liver Function Tests (LFT's) with fatty liver on ultrasound and biopsy
proven NASH
Exclusion Criteria:
- significant history of alcohol consumption > 20 gm/day (> 2 drinks / day)
- evidence of other causes of hepatitis including positive screening B & C, autoimmune
hepatitis, hemochromatosis, celiac disease, Wilson's disease, alpha 1 antitrypsin
deficiency or medication-induced hepatitis
- Subjects with planned exercise > 30-60 minutes per week
- BMI < 25 or > 44 kg/m2
- clinical or biochemical evidence of decompensated liver disease, advanced cardiac or
renal disease
- changes in last 3 months the dose of oral hypoglycemic medication and statin,
- positive stress test
- pregnant women
- demented individuals who cannot give consent
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| NCT ID: |
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NCT01327443 |
| Primary Contact: |
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Principal Investigator
Jamal Ibdah, MD; PhD
University of Missouri-Columbia
Abhishek Choudhary, MD
Phone: 573 882 7349
Email: choudharya@health.missouri.edu
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| Backup Contact: |
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Email: rectors@health.missouri.edu
Scott Rector, PhD
Phone: 573 882 7349
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| Location Contact: |
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Columbia, Missouri 65212
United States
There is no listed contact information for this specific location.
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 18, 2013 |
| Modifications to this listing: |
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