View Clinical Trial (Medical Research Study)

Effect of Pregabalin on Colonic Motor and Sensory Function in Adults With Irritable Bowel Syndrome With Predominant Constipation

This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials

---

Conditions:		Irritable Bowel Syndrome
Purpose:		The general aim of the current study is to describe the effect of pregabalin on colonic and sensory functions in Adults with Constipation Predominant Irritable Bowel Syndrome.
Study Summary:		Specific aims of the protocol: 1. To quantify the effect of a single administration of 200mg pregabalin on colonic sensory and motor functions in constipation predominant IBS adults. 2. To assess the potential relationship between any analgesic properties of pregabalin and its effect on compliance in constipation predominant IBS adults. 3. To estimate if pregabalin 200mg dose reduces colonic sensation ratings and increases pain thresholds by 50% related to placebo.
Criteria:		Inclusion criteria: Male or females with Constipation Predominant IBS, age 18-65 Exclusion criteria: 1. abdominal surgery other than appendectomy, laparoscopic cholecystectomy, cesarean section, vaginal or laparoscopic hysterectomy or tubal ligation, 2. uncontrolled hypertension, 3. use of medications that may interact with the study medication, 4. use of any of the study medications within the past 30 days, 5. pregnancy, 6. history of chronic renal insufficiency (serum creatinine >1.5mg/dL) and 7. psychiatric or psychologic dysfunction 8. current pelvic floor dysfunction
NCT ID:		NCT01331213
Primary Contact:		Principal Investigator Michael Camilleri, MD Mayo Clinic
Backup Contact:		N/A
Location Contact:		Rochester, Minnesota 55905 United States There is no listed contact information for this specific location. Site Status: N/A

---

---