View Clinical Trial (Medical Research Study)
The Impact of Fitness on Vascular Dysfunction in Adolescents With Type 1 Diabetes
| City: |
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Charlottesville |
| State: |
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Virginia |
| Zip Code: |
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22903 |
| Conditions: |
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Type 1 Diabetes |
| Purpose: |
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The principal hypothesis of this study is that the micro and macro vasculature of young
diabetes mellitus type 1 (DM1) patients is particularly susceptible to atherogenic factors
which cause vascular dysfunction at multiple levels of the arterial vasculature and that
this dysfunction is demonstrable using state-of-the-art ultrasound methods. The
investigators further hypothesize that interventions, such as exercise, that are readily
integrated into the daily life of individuals with DM1 can mitigate or reverse these early
vascular changes and thereby diminish the otherwise predictable longer-term development of
cardiovascular disease (CVD) in type 1 DM
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria: You may be eligible if you are:
- Male or female, 12-18 years of age
- Healthy, no chronic illness other than DM1
- No medications that would affect the blood vessels
- Non-smoker
- Normal height and weight
Requirements for both groups (study 1)
- Two outpatient visits lasting ~1 to 1 ½ hours
- 1 outpatient admission lasting ~ 10 hrs
- Most visits require blood draws Requirements for second part of study for DM1 group
(study 2)
- Two additional outpatient visits (one requires blood draw)
- 12 weeks of an exercise program (5 days per week, 3 of them here at UVA)
- Maintain healthy diet for those 12 weeks-you will have diet instruction
- Repeat outpatient admission as described above
Exclusion Criteria:
- under 12 or over 18 years of age
- medication that could affect the blood vessels
- smoker
- above average BMI
- chronic illness other than DM1
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| NCT ID: |
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NCT01337947 |
| Primary Contact: |
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Principal Investigator
Eugene Barrett, MD
University of Virginia
Linda Jahn, RN, MEd
Phone: 434-924-1134
Email: las6e@virginia.edu
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| Backup Contact: |
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Email: lmh9d@virginia.edu
Lee Hartline, MEd
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| Location Contact: |
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Charlottesville, Virginia 22903
United States
Linda Jahn, RN, MEd
Phone: 434-924-1134
Email: las6e@virginia.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 18, 2013 |
| Modifications to this listing: |
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