The Functional Neuroanatomy of Catastrophizing: an fMRI Study
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| City: |
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Chestnut Hill |
| State: |
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Massachusetts |
| Zip Code: |
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02467 |
| Conditions: |
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Fibromyalgia |
| Purpose: |
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This is a brain imaging study of pain responses. The study includes 2-7 visits, lasting from
1-2 hours each. You may be eligible if you are over 18 years old, are either generally
healthy or have fibromyalgia, do not have a serious heart condition or certain other medical
conditions, are not taking certain types of medications, and are not pregnant.The research
takes place at the Brigham & Women's Pain Management Center, 850 Boylston St, Chestnut Hill,
and at the MGH Martinos Center for Biomedical Imaging. For further information, please
contact the study coordinator Chrissie Cahalan at 617-732-9014 or by email at
CCahalan1@partners.org.
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| Study Summary: |
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This research is being done to learn about brain activation during brief applications of
painful stimuli using MRI, a technique for making images pictures of the brain. MRI uses
magnetic fields and radio waves and is not harmful. This study uses a new investigational
technique called functional MRI (fMRI) which is a very fast MRI technique that will allow
the investigators to evaluate changes in how blood flows to parts of your brain during the
experience of pain. Findings from this study will have implications for understanding
individual differences in the experience of pain.
If you are over 18 and have Fibromyalgia or are generally healthy, you may be eligible.
Other eligibility criteria include: no major circulation or heart problems, nerve damage,
and no use of certain kinds of medications or other substances. This study involves a first
visit to the Brigham & Women's Pain Management Center, and a second visit to the MRI
facility at MGH.
The first visit will be a screening visit, lasting around 2 hours. The second visit will
involve a session of fMRI assessment and will last around 2 hours. Both of these visits will
involve 2 kinds of tests to measure your sensory responses to pressure. For all of these
tests, you can stop at any time.
Depending on your responses to pain, you may be invited to participate in a follow-up
treatment study. This involves 4 visits with Dr. Edwards, the clinical psychologist and
principle investigator of this study, for therapy that addresses thoughts about pain or
Fibromyalgia education. These sessions will be followed by another fMRI visit identical to
visit 2. You do not have to participate in this study, and if you start the study you can
leave at any time without affecting your future treatment or participation in research
studies.
If you would like to learn more about the study, please contact the study coordinator
Chrissie Cahalan (617-732-9014 or ccahalan1@partners.org).
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| Criteria: |
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Inclusion Criteria:
- Age 18 or older
- Meet ACR criteria for RA or FM or be free from chronic pain and rheumatic disease
- Score on the Pain Catastrophizing Scale in either the top or bottom third of the
normative distribution
Exclusion Criteria:
- History of anxiety disorders or significant anxiety symptoms interfering with fMRI
procedures (e.g., panic)
- History of cardiac events
- History of significant head injury
- Peripheral neuropathy
- Use of certain centrally-acting analgesic medications other than over-the-counter
preparations (which will be withdrawn for 24 hours prior to testing) or use of
recreational drugs
- Implanted medical or metallic objects
- Pregnancy
- Cardiac or nervous system disease
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| NCT ID: |
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NCT01345344 |
| Primary Contact: |
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Principal Investigator
Robert R Edwards, PhD
Brigham and Women's Hospital
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| Backup Contact: |
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N/A |
| Location Contact: |
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Chestnut Hill, Massachusetts 02467
United States
There is no listed contact information for this specific location.
Site Status: N/A |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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June 18, 2013 |
| Modifications to this listing: |
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