View Clinical Trial (Medical Research Study)
Escitalopram (Lexapro) for the Treatment of TBI Depression and Other Comorbid Psychiatric Conditions
| City: |
|
Baltimore |
| State: |
|
Maryland |
| Zip Code: |
|
21224 |
| Conditions: |
|
TBI - Major Depression - Other Psychiatric Disorders |
| Purpose: |
|
This research is being done to see if a drug called escitalopram (Lexapro) is helpful to
people who are suffering from depression after traumatic brain injury (TBI).
|
| Study Summary: |
|
Despite it's high prevalence, little is known about the pharmacological treatment of
depression following Traumatic Brain Injury (TBI). This is because of a lack of randomized
controlled studies in the treatment of post-TBI depression. This study is designed to
examine the safety and effectiveness of escitalopram in the treatment of post-TBI
depression. It will also investigate metabolic changes and neural pathways associated with
post-TBI depression and metabolic alterations after treatment through neuroimaging.
|
| Criteria: |
|
Inclusion Criteria:
- Closed head injury
- Fulfill DSM IV criteria "Major Depressive Disorder"
- 18 years of age or older
- Able to provide informed consent
- Stable medical history
Exclusion Criteria:
- History of Stroke, Encephalitis, Seizures, or any other pre-TBI neurological diseases
- History of mental retardation
- Alcohol or Substance dependence in the last 1 year
- Inability to undergo MRI scan
- Pregnancy
- Current use of any psychotropic medications including any antidepressants,
antipsychotics, anxiolytics, or sedative hypnotics
- Poor response to escitalopram in the past
- Acutely suicidal or requiring inpatient psychiatric hospitalization, as determined by
the study psychiatrist
- Good medication response to another antidepressant in the past
|
| NCT ID: |
|
NCT01368432 |
| Primary Contact: |
|
Principal Investigator
Vani Rao, M.D
Johns Hopkins University
Alyssa Bergey, M.A.
Phone: 410-550-9022
Email: abergey1@jhmi.edu
|
| Backup Contact: |
|
N/A |
| Location Contact: |
|
Baltimore, Maryland 21224
United States
Alyssa Bergey, M.A.
Phone: 410-550-9022
Email: abergey1@jhmi.edu
Site Status: Recruiting |
| Data Source: |
|
ClinicalTrials.gov |
| Date Processed: |
|
June 19, 2013 |
| Modifications to this listing: |
|
Only selected fields are shown, please use the link
below to view all information about this clinical trial. |
|
Click to view Full Listing
|