View Clinical Trial (Medical Research Study)
Physiological Study to Predict Successful Sleep Apnea Treatment With Acetazolamide in Heart Failure Patients
| City: |
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Boston |
| State: |
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Massachusetts |
| Zip Code: |
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02115 |
| Conditions: |
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Heart Failure |
| Purpose: |
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The ultimate goal is to improve our understanding of the pathophysiology and resistance to
effective treatment of sleep disordered breathing in patients with heart failure, with a
focus on selecting patients that will benefit specifically from acetazolamide treatment.
The study addresses three primary hypotheses: 1) Acetazolamide treatment will reduce the
apnea-hypopnea index and improve markers of heart-failure severity in heart-failure patients
with sleep apnea. 2) Acetazolamide will provide the greatest improvement in patients with
the least severe ventilatory control instability (lowest loop gain). 3) Acetazolamide will
act primarily via stabilizing ventilatory control (reducing loop gain), rather than via
improvement to upper airway anatomy, pulmonary congestion, and cardiac function.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
- LVEF<50%
- Age 18-80
Exclusion Criteria:
- severe obstructive respiratory disease
- unstable heart failure status
- recent use of positive airway pressure therapy
- current use of medications known to affect ventilation
- severe kidney disease
- hemoglobin <9.5g/dl (moderate-severe anemia)
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| NCT ID: |
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NCT01377987 |
| Primary Contact: |
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Principal Investigator
Atul Malhotra, MD
Brigham and Women's Hospital
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| Backup Contact: |
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N/A |
| Location Contact: |
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Boston, Massachusetts 02115
United States
Scott A Sands, PhD
Email: sasands@partners.org
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 24, 2013 |
| Modifications to this listing: |
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