View Clinical Trial (Medical Research Study)
Regulation of Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease: A Mechanistic Approach
| City: |
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Augusta |
| State: |
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Georgia |
| Zip Code: |
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30912 |
| Conditions: |
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Pulmonary Disease, Chronic Obstructive |
| Purpose: |
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More patients with chronic obstructive pulmonary disease (COPD) die from cardiovascular
disease than direct pulmonary complications. Inflammation and oxidative stress,
characteristic in COPD, are likely contributors to the reduction in nitric oxide (NO)
bioavailability and vascular endothelial dysfunction in COPD patients; however, this has yet
to be determined. Thus, the overall objective of this proposal is to identify the role of NO
bioavailability in contributing to vascular endothelial dysfunction in patients with COPD
and to provide insight into the molecular mechanisms involved. Our central hypothesis is
that inflammation and oxidative stress, both independently, contribute to the reduction in
NO bioavailability and vascular endothelial dysfunction in patients with COPD.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
- Patients with COPD (GOLD stages II-IV) and matched healthy controls
- Caucasian or African American
- Both men and women
- Current and former smokers
Exclusion Criteria:
- GOLD Stage I
- Clinical diagnosis of heart disease, hypertension, or metabolic disease
- Vasoactive medications (i.e. nitrates, beta-blockers, ACE inhibitors, Viagra, etc.)
- Pulmonary hypertension
- Hypothyroidism
- Hyper-homocysteinemia
- Interstitial lung disease
- Phenylketonuria
- Pregnancy
- Sleep apnea
- Anemia
- Raynod's phenomenon
- Gangrene of the digits
- History of low platelets or coagulopathies
- Aspirin sensitivity or allergy
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| NCT ID: |
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NCT01398943 |
| Primary Contact: |
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Principal Investigator
Ryan A Harris, PhD
Georgia Health Sciences University
Ryan A Harris, PhD
Phone: 706-721-5998
Email: ryharris@georgiahealth.edu
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| Backup Contact: |
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Email: masiegler@georgiahealth.edu
Nichole Siegler, BS
Phone: 706-721-5998
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| Location Contact: |
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Augusta, Georgia 30912
United States
Ryan A Harris, PhD
Phone: 706-721-5998
Email: ryharris@georgiahealth.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 24, 2013 |
| Modifications to this listing: |
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