View Clinical Trial (Medical Research Study)
Cognitive Remediation for Neuropsychological Impairment in Compulsive Hoarding
| City: |
|
Hartford |
| State: |
|
Connecticut |
| Zip Code: |
|
06106 |
| Conditions: |
|
Hoarding Disorder - Attentional Impairment |
| Purpose: |
|
The primary aim of this pilot randomized controlled trial is to examine whether cognitive
remediation, compared to a placebo, improves attention and related cognitive functions in
patients with compulsive hoarding. The primary hypothesis is that compulsive hoarding
patients who are treated with cognitive remediation will demonstrate improved cognitive
skills at post-treatment compared to patients receiving placebo. This will be especially
true of attention; memory and executive function skills may also be improved.
|
| Study Summary: |
|
The primary aim of this pilot randomized controlled trial is to examine whether cognitive
remediation, compared to a placebo, improves attention and related cognitive functions in
patients with compulsive hoarding. Previous research has demonstrated that hoarders have
diminished neuropsychological abilities, particularly in the areas of attention, memory, and
executive function; and that cognitive remediation improves those functions in populations
that are similarly impaired, such as in individuals with schizophrenia. The investigators
will thus randomize 20 patients with compulsive hoarding to receive either cognitive
remediation or a placebo condition. Before and after treatment, the investigators aim to
assess the effects of cognitive remediation on neuropsychological functioning and hoarding
severity. The primary specific aim is to examine whether cognitive remediation improves
cognitive function in compulsive hoarders. The investigators hypothesize that compulsive
hoarding patients who are treated with cognitive remediation will demonstrate improved
cognitive skills at post-treatment compared to patients receiving placebo. This will be
especially true of attention; memory and executive function skills may also be improved. A
secondary, exploratory aim is to examine whether cognitive remediation improves hoarding
severity, compared to placebo. The ultimate goal of this research is to determine the
feasibility and appropriateness of pursuing larger-scale studies of the promising new
approach of combining cognitive remediation with other treatments for compulsive
hoarding—particularly cognitive-behavioral therapy (CBT).
|
| Criteria: |
|
Inclusion Criteria:
- be over 18 years of age,
- have a current primary diagnosis of hoarding disorder
- have no untreated and/or unstable concurrent psychiatric diagnoses
- have a score on the ADHDSS that is one standard deviation or more above the mean
- have an Attentional Composite score on the computerized battery of neuropsychological
tests (Doniger, 2010) that is one standard deviation or more below the mean
- be stable on all psychotropic medications during and up to four weeks preceding
enrollment in the study
Exclusion Criteria:
- currently taking any cognitive enhancers or stimulants
- people with a history of Multiple Sclerosis, Traumatic Brain Injury, loss of
consciousness lasting more than 5 minutes, seizures, dementia, or other organic
brain-related disorders
- current Alcohol or Substance Abuse and/or a history of Alcohol or Substance
Dependence
|
| NCT ID: |
|
NCT01451697 |
| Primary Contact: |
|
Principal Investigator
Jennifer DiMauro, BA
Hartford Hospital
Jennifer DiMauro, BA
Phone: 860-545-7707
Email: jdimauro@harthosp.org
|
| Backup Contact: |
|
Email: dtolin@harthosp.org
David F Tolin, PhD
Phone: 860-545-7685
|
| Location Contact: |
|
Hartford, Connecticut 06106
United States
Jennifer DiMauro, BA
Phone: 860-545-7707
Email: jdimauro@harthosp.org
Site Status: Recruiting |
| Data Source: |
|
ClinicalTrials.gov |
| Date Processed: |
|
May 25, 2013 |
| Modifications to this listing: |
|
Only selected fields are shown, please use the link
below to view all information about this clinical trial. |
|
Click to view Full Listing
|