View Clinical Trial (Medical Research Study)
Progressive Metabolic Adaptations to Low Intensity Exercise Training and Weight Loss
| City: |
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Ann Arbor |
| State: |
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Michigan |
| Zip Code: |
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48109 |
| Conditions: |
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Obesity |
| Purpose: |
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the investigators first aim is to determine the effect of low intensity exercise (without
weight loss) on insulin sensitivity, muscle lipid metabolism, and factors regulating these
processes in skeletal muscle after 1 day, 2 wks, 12 wks of training, and again after 3 days
without exercise in obese adults. the investigators second aim is to determine the effect of
combining low intensity exercise training with 10% weight loss on insulin sensitivity,
muscle lipid metabolism, and factors regulating these processes in skeletal muscle.
Although a single 40 minute session of exercise at a low exercise intensity will not improve
insulin sensitivity, the investigators anticipate adaptations after two weeks of exercise
training (6 session/wk; 12 session total) will improve insulin sensitivity and be
accompanied by a reduction in fatty acid intermediates and a reduction in markers for
pro-inflammatory activation in muscle. the investigators anticipate changes in insulin
sensitivity, fatty acid partitioning, and pro-inflammatory markers the day after the last
session of a 12 wk training program (without weight-loss) will be similar to that measured
after 2 weeks of training. the investigators anticipate insulin sensitivity, accumulation of
fatty acid intermediates, and pro-inflammatory activation will be markedly improved after
10% weight loss when measured the day after exercise. the investigators would expect the
improvements in Insulin sensitivity, accumulation of fatty acid intermediates, and markers
of inflammatory stress will be significantly attenuated when measured 3 days after the most
recent exercise session, but beneficial effects of 10% weight loss on these metabolic
endpoints will persist when compared with before weight loss.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
- body mass index [BMI]: 30-45 kg/m2; All women must be pre-menopausal; Non-exerciser
(no regularly planned exercise/physical activity)
Exclusion Criteria:
- Hematocrit ≤ 34%; Fasting plasma glucose concentration ≥ 125 mg/dL; Weight
instability ≥ ±5 lbs in past month; Taking medications known to affect lipid and/or
glucose metabolism; evidence and/or history of cardiovascular or frank metabolic
diseases; pregnancy or actively breast feeding
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| NCT ID: |
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NCT01452074 |
| Primary Contact: |
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Principal Investigator
Jeffrey F Horowitz
University of Michigan
Suzette Howton, RD
Phone: 734-647-9850
Email: suzetter@med.umich.edu
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| Backup Contact: |
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N/A |
| Location Contact: |
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Ann Arbor, Michigan 48109
United States
Suzette Howton, RD
Phone: 734-647-9850
Email: suzetter@med.umich.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 25, 2013 |
| Modifications to this listing: |
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