View Clinical Trial (Medical Research Study)
Changes in Adipokines and Adiposity During Puberty and Young Adulthood
| City: |
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Salt Lake City |
| State: |
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Utah |
| Zip Code: |
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84108 |
| Conditions: |
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Obesity |
| Purpose: |
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The investigators propose to conduct a cross-sectional study of 60 participants who are
18-30 years of age to undergo research PET/CT. The purpose of this study is to investigate
the relationships between Brown Adipose Tissue (BAT), the adiponectin/leptin (A/L) ratio,
and components of the metabolic syndrome in young adults.
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| Study Summary: |
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We propose to conduct a cross-sectional study of 60 participants who are 18-30 years of age
to undergo research PET/CT. The purpose of this study is to investigate the relationships
between Brown Adipose Tissue (BAT), the adiponectin/leptin (A/L) ratio, and components of
the metabolic syndrome in young adults. This study is part of a larger study aimed at
understanding the mechanism of brown adipose tissue as a potential protective factor against
metabolic dysfunction.
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| Criteria: |
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Inclusion Criteria:
- Males and females, 18-30 years of age at enrollment, who are obese (BMI greater or
equal to 30 kg/m2, weight less than 159 kg) and healthy
- Without medications and endocrine/genetic disorders known to affect weight.
- Participants may have insulin resistance, impaired glucose tolerance, dyslipidemia,
or hypertension.
Exclusion Criteria:
- Anyone who refuses participation.
- A genetic syndrome or other endocrine disorder known to cause obesity (Prader-Willi,
Cushing Syndrome, Leptin deficiency, etc.).
- Use of the following medications: psychotropics, sulphonylurea, thiazolidinediones,
insulin, glucocorticoids, anti-neoplastic agents, angiotensin receptor blocker,
angiotensin-converting enzyme inhibitors.
- Pregnancy or history of pregnancy.
- Active infectious disease
- History of CVD or stroke during the previous 36 months
- Total cholesterol 300 mg/dl, triglycerides 400 mg/dl
- Blood pressure 140/90 mmHg
- Fasting plasma glucose 126 mg/dl.
- Diabetes mellitus, type 1 or 2.
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| NCT ID: |
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NCT01460784 |
| Primary Contact: |
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Principal Investigator
Nicole Mihalopoulos
University of Utah, Department of Pediatrics, Division of Adolescent Medicine
Nicole Mihalopoulos
Phone: 801-585-6334
Email: nicole.mihalopoulos@hsc.utah.edu
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| Backup Contact: |
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N/A |
| Location Contact: |
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Salt Lake City, Utah 84108
United States
Nicole L Mihalopoulos, MD
Phone: 801-585-6334
Email: nicole.mihalopoulos@hsc.utah.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 19, 2013 |
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