View Clinical Trial (Medical Research Study)
Urinary 8-isoprostane is Elevated in Acute Childhood Asthma
| City: |
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Stony Brook |
| State: |
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New York |
| Zip Code: |
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11794 |
| Conditions: |
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Childhood Asthma - Oxidative Stress |
| Purpose: |
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Oxidative stress is seen in children with asthma, but is hard to measure. The investigators
exploring the utility of using a commercially available assay to measure oxidative stress in
the urine in asthmatics. Additionally, the investigators will attempt to prove that
oxidative stress is higher in children with acute asthma compared to those with stable
asthma and that this stress is also higher in children with more severe clinical asthma
exacerbations compared to less severe ones.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
Group 1
1. Patients aged 4-18 years
2. Known stable asthmatics on no medications or with no medication changes in 3
weeks prior to enrollment
3. No asthma hospitalizations in past 3 months
4. Parent available to consent
Group 2
1. Patients aged 4-18
2. Known asthmatic, admitted to Stony Brook University Hospital for status asthmaticus
3. Parent available to consent
Exclusion Criteria:
1. Any child with documented fever within 24 hours of study entry
2. Any child with a known current history of tracheo- or bronchomalacia
3. Any child with known clinical or laboratory evidence of shock (see below)
4. Any child with history of documented immunodeficiency, rheumatologic disease, cystic
fibrosis, or renal dysfunction (see below)
5. Any child with a current or recent (less than 1 year) history of tracheostomy
6. Any child with a known genetic abnormality
7. Any pregnant child
8. Any child with a history of autism
9. Any child whose parent/caregiver is unable to give informed consent
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| NCT ID: |
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NCT01472471 |
| Primary Contact: |
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Principal Investigator
Daniel E Sloniewsky, MD
Long Island Children's Hospital at Stony Brook
Daniel Sloniewsky, MD
Phone: 631-444-8211
Email: daniel.sloniewsky@sbumed.org
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| Backup Contact: |
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N/A |
| Location Contact: |
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Stony Brook, New York 11794
United States
Daniel E Sloniewsky, MD
Phone: 631-444-8211
Email: daniel.sloniewsky@sbumed.org
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 20, 2013 |
| Modifications to this listing: |
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