View Clinical Trial (Medical Research Study)
A Composite MR Neuroimaging Marker for Alzheimer's Disease
| City: |
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Milwaukee |
| State: |
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Wisconsin |
| Zip Code: |
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53226 |
| Conditions: |
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Alzheimer's Disease - Mild Cognitive Impairment - Frontotemporal Dementia |
| Purpose: |
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The purpose of this study is to use a functional MRI (fMRI) index to compare the brain
activity of healthy volunteers to that of people with mild cognitive impairment (MCI) and
Alzheimer's disease. The ultimate goal is to develop an early diagnostic tool for
Alzheimer's disease.
The study hypotheses are:
1. The fMRI index will differentiate between Alzheimer's disease, non-Alzheimer's
dementia, and healthy volunteers;
2. The fMRI index will distinguish participants with MCI who convert to Alzheimer's
disease from those who convert to a non-Alzheimer's dementia and those who remain
stable;
3. MCI participants with a lower fMRI index at baseline who convert will progress to
Alzheimer's sooner than those with a higher fMRI index, and MCI participants with a
faster rate of fMRI index decline who convert will have an earlier onset of Alzheimer's
disease.
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| Study Summary: |
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The onset of Alzheimer's disease is insidious and the boundary between normal aging and
Alzheimer's disease is blurred. In order to prevent and treat Alzheimer's disease, the
investigators must be able to mark its preclinical stage, before brain damage becomes
irreversible. There is a substantial body of research dealing with predictive markers of
Alzheimer's disease in individuals with mild cognitive impairment (MCI). Despite these
advances, however, researchers have not had enough evidence to recommend specific techniques
that mark preclinical Alzheimer's disease. This new functional MRI (fMRI) index may fill
this gap.
Participants will have two visits, one for memory testing and neurological examination, and
one for an MRI scan. Each visit will take approximately 1½ hours. For volunteers who wish
to do so, all study procedures may be completed in a single visit. Participants with MCI
will be followed annually.
The investigators are currently enrolling healthy volunteers, as well as individuals with
MCI (memory loss that does not significantly affect normal daily activities), Alzheimer's
disease, and frontotemporal dementia (includes primary progressive aphasia).
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| Criteria: |
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Inclusion Criteria:
- 60 years of age or older (50 years of age or older for frontotemporal dementia
patients)
- Normal memory, mild cognitive impairment (memory loss that does not significantly
affect normal daily activities), or clinical diagnosis of Alzheimer's disease or
frontotemporal dementia (includes primary progressive aphasia)
- Right-handed
- General good physical health
Exclusion Criteria:
- History of stroke or neurological disease (other than Alzheimer's disease or
frontotemporal dementia)
- Seizures or head injury with loss of consciousness within the last five years
- Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner)
- Claustrophobia
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| NCT ID: |
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NCT01615666 |
| Primary Contact: |
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Principal Investigator
Shi-Jiang Li, PhD
Medical College of Wisconsin
Jennifer Jones, MS, CCRC
Phone: 414-805-5232
Email: jljones@mcw.edu
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| Backup Contact: |
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N/A |
| Location Contact: |
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Milwaukee, Wisconsin 53226
United States
There is no listed contact information for this specific location.
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 24, 2013 |
| Modifications to this listing: |
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